Category Archives: Uncategorized

PMID:  Biotech Histochem. 2019 Jan ;94(1):10-25. Epub 2018 Aug 13. PMID: 30101628 Abstract Title:  Paeonol exhibits anti-tumor effects by apoptotic and anti-inflammatory activities in 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis. Abstract:  We investigated the preventive potential of paeonol on 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinogenesis. Oral tumors were developed in the buccal pouches of Syrian golden hamsters using …

Continue reading “Paeonol exhibited protective effects against DMBA induced oral carcinogenesis.”

PMID:  Evid Based Complement Alternat Med. 2018 ;2018:3063145. Epub 2018 Aug 15. PMID: 30186353 Abstract Title:  Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-B and MAPK Signaling. Abstract:  Asthma is a chronic inflammatory disease of the airways, with complex signaling pathways involved in its pathogenesis. It was reported that paeonol attenuated airway inflammation of …

Continue reading “Paeonol ameliorated ovalbumin-induced asthma through the TLR4/NF-κB and mitogen-activated protein kinase signalling.”

PMID:  Biochimie. 2019 Jan ;156:129-137. Epub 2018 Sep 10. PMID: 30213522 Abstract Title:  Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-κB/NFATc1 signaling pathway. Abstract:  Paeonol is a natural phenolic compound in Moutan Cortex with multiple biological functions, such as anti-inflammatory and anti-oxidant activity. Recent evidence has proven that persistent inflammation, oxidative …

Continue reading “These results showed that paeonol protected against periodontitis-aggravated osteoclastogenesis and alveolar bone lesion.”

PMID:  Hum Exp Toxicol. 2019 May ;38(5):510-518. Epub 2018 Dec 24. PMID: 30580614 Abstract Title:  Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats. Abstract:  Paeonol, a natural phenolic compound, possesses diverse beneficial effects including antioxidant and anti-inflammatory effects. Gastric ulcer is still the most prevalent irritant illness among the gastrointestinal diseases. The …

Continue reading “Mechanisms underlying gastroprotective effect of paeonol against indomethacin-induced ulcer in rats.”

PMID:  Front Pharmacol. 2018 ;9:1105. Epub 2018 Nov 20. PMID: 30515094 Abstract Title:  Paeonol Attenuated Inflammatory Response of Endothelial Cells via Stimulating Monocytes-Derived Exosomal MicroRNA-223. Abstract:  Paeonol, an active compound isolated from the radix of, has been shown to have anti-atherosclerosis effects by regulating blood cells' function and protecting vascular cells injury. Besides, emerging evidences …

Continue reading “Paeonol attenuated inflammatory response of endothelial cells via stimulating monocytes-derived exosomal microRNA-223.”

PMID:  Oxid Med Cell Longev. 2018 ;2018:1098617. Epub 2018 Nov 7. PMID: 30524649 Abstract Title:  Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis. Abstract:  Atherosclerosis, a chronic luminal stenosis disorder occurred in large and medium arteries, is the principle pathological basis of cardiovascular diseases with the highest morbidity and mortality worldwide. In oriental …

Continue reading “A review of the beneficial effects exerted by paeonol in the management of atherosclerosis.”

PMID:  Oncol Lett. 2019 Feb ;17(2):1761-1767. Epub 2018 Nov 19. PMID: 30675235 Abstract Title:  Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway. Abstract:  The aim of the study was to investigate the effect of paeonol on the apoptosis of hepatocellular carcinoma cells and to explore the possible mechanism of its effect. During the experiment, …

Continue reading “Paeonol-mediated apoptosis of hepatocellular carcinoma cells by NF-κB pathway.”

PMID:  Pharmazie. 2019 02 1 ;74(2):101-106. PMID: 30782259 Abstract Title:  Paeonol ameliorates lipopolysaccharides-induced acute lung injury by regulating TLR4/MyD88/ NF-κB signaling pathway. Abstract:  Paeonol has been found to hold analgesic, antipyretic and anti-allergic activities. Here, we investigated the protective effect of paeonol on acute lung injury (ALI) induced by lipopolysaccharides (LPS) and explored the underlying …

Continue reading “This study provides evidence for the application of paeonol in treating acute lung injury.”

PMID:  Front Pharmacol. 2019 ;10:261. Epub 2019 Mar 19. PMID: 30941042 Abstract Title:  Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt. Abstract:  Our previous study proved that paeonol (Pae) could lower blood glucose levels of diabetic mice. There are also a few reports of its potential use for diabetes treatment. However, …

Continue reading “Paeonol ameliorates glucose and lipid metabolism in experimental diabetes by activating Akt.”

PMID:  Immunopharmacol Immunotoxicol. 2019 Jun ;41(3):438-445. Epub 2019 May 23. PMID: 31119954 Abstract Title:  Paeonol alleviates CCl-induced liver fibrosis through suppression of hepatic stellate cells activation via inhibiting the TGF-β/Smad3 signaling. Abstract:  Paeonol is a natural phenolic component isolated from the root bark of peony with multiple pharmacological activities. We investigated the anti-fibrotic effect and …

Continue reading “These data demonstrated that paeonol could alleviate carbon tetrachloride-induced liver fibrosis.”