PMID: Dose Response. 2019 Apr-Jun;17(2):1559325819843383. Epub 2019 May 2. PMID: 31080379 Abstract Title: Association of Increased Risk of Pneumonia and Using Proton Pump Inhibitors in Patients With Type II Diabetes Mellitus. Abstract: Background: This study explored the possible association between the use of proton pump inhibitors (PPIs) and the increased incidence of pneumonia in patients …
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Proton pump inhibitors use was associated with an increased risk of developing clostridium difficile infection.
PMID: J Gastroenterol. 2019 Jun 11. Epub 2019 Jun 11. PMID: 31187275 Abstract Title: Effects of proton pump inhibitor use on risk of Clostridium difficile infection: a hospital cohort study. Abstract: BACKGROUND: Although there are several studies on the association between use of proton pump inhibitors (PPIs) and increased Clostridium difficile infection (CDI) risk, detailed …
Proton pump inhibitors are able to modify the host microbiota in each segment of the GI tract and can contribute to dysbiosis development.
PMID: World J Gastroenterol. 2019 Jun 14 ;25(22):2706-2719. PMID: 31235994 Abstract Title: Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified. Abstract: Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal …
Proton pump inhibitors use was associated with progression to major adverse renal events in patients with chronic kidney disease.
PMID: QJM. 2019 Jun 28. Epub 2019 Jun 28. PMID: 31251364 Abstract Title: Proton Pump Inhibitor Use and Progression to Major Adverse Renal Events: A Competing Risk Analysis. Abstract: BACKGROUND: Proton pump inhibitors (PPIs) are associated with acute tubulointerstitial nephritis and there are reports associating their use with the development of chronic kidney disease (CKD).AIM: …
Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients.
PMID: World J Hepatol. 2019 Jun 27 ;11(6):522-530. PMID: 31293720 Abstract Title: Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients. Abstract: BACKGROUND: Liver cirrhosis is the late stage of hepatic fibrosis and is characterized by portal hypertension that can clinically lead to decompensation in the form of ascites, esophageal/gastric varices or …
There was a statistically significant association between use of proton pump inhibitors and dementia diagnosis.
PMID: Fed Pract. 2019 Jun ;36(Suppl 4):S27-S31. PMID: 31296980 Abstract Title: Proton Pump Inhibitor Use and Risk of Dementia in the Veteran Population. Abstract: There was a statistically significant association between use of proton pump inhibitors and dementia diagnosis in a 11-year retrospective study of patients at the Sioux Falls Veteran Affairs Health Care System. …
The use of proton pump inhibitors can increase the risk of infections in patients with hepatitis C.
PMID: Scand J Gastroenterol. 2019 Jul 30:1-9. Epub 2019 Jul 30. PMID: 31361979 Abstract Title: The impact of proton pump inhibitors on the intestinal microbiota in chronic hepatitis C patients. Abstract: Proton pump inhibitors (PPI), a class of drugs commonly used, are known to be associated with changes in the intestinal microbiota. Published studies were …
Proton pump inhibitor use was associated with an increased risk of gastric and oesophageal cancer.
PMID: Cancer Epidemiol. 2019 Aug 21 ;62:101585. Epub 2019 Aug 21. PMID: 31445426 Abstract Title: Duration of use of proton pump inhibitors and the risk of gastric and oesophageal cancer. Abstract: BACKGROUND: There is increasing interest in the potential association between proton pump inhibitors (PPIs) and the risk of gastric and oesophageal cancer, yet the …
Proton pump inhibitor use was associated with an increased risk of cholangitis.
PMID: Aliment Pharmacol Ther. 2019 Aug 25. Epub 2019 Aug 25. PMID: 31448440 Abstract Title: Use of proton pump inhibitors and risk of cholangitis: a nationwide cohort study. Abstract: BACKGROUND: Proton pump inhibitor (PPI) use may alter the gut microbiome and increase the risk of cholangitis. However, the association of PPI use with the risk …
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Deleterious effect of proton pump inhibitors on the disease course of cirrhosis.
PMID: Eur J Gastroenterol Hepatol. 2019 Aug 27. Epub 2019 Aug 27. PMID: 31464790 Abstract Title: Deleterious effect of proton pump inhibitors on the disease course of cirrhosis. Abstract: OBJECTIVES: Proton pump inhibitors(PPIs) are widely prescribed to patients with liver cirrhosis. We hypothesized that long-standing PPI use is associated with spontaneous bacterial peritonitis(SBP) and accelerated …
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