PMID: EXCLI J. 2019 ;18:1019-1036. Epub 2019 Nov 5. PMID: 31762726 Abstract Title: Transgenerational influence of parental morphine exposure on pain perception, anxiety-like behavior and passive avoidance memory among male and female offspring of Wistar rats. Abstract: Accumulating evidence suggests that epigenetic mechanisms play an important role in the formation and maintenance of memory within …
Author Archives: Taylor Mercado
Developmental exposure to lead induces transgenerational changes to zebrafish brain transcriptome.
PMID: Chemosphere. 2019 Dec 2 ;244:125527. Epub 2019 Dec 2. PMID: 31816550 Abstract Title: Developmental exposure to Pbinduces transgenerational changes to zebrafish brain transcriptome. Abstract: Lead (Pb) is a major public health hazard for urban children, with profound and well-characterized developmental and behavioral implications across the lifespan. The ability of early Pbexposure to induce epigenetic …
Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice.
PMID: Exp Mol Med. 2020 Jan 24. Epub 2020 Jan 24. PMID: 31974504 Abstract Title: Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice. Abstract: Renal and cardiovascular complications of prematurity are well established, notably the development of hypertension in adulthood. However, the underlying molecular mechanisms remain poorly understood. Our objective was …
N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis.
PMID: Free Radic Biol Med. 2019 01 ;130:512-527. Epub 2018 Nov 15. PMID: 30447351 Abstract Title: N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation. Abstract: The mechanism underlying the development of chronic kidney disease (CKD) after acute kidney injury (AKI) remains unclear. Maladaptive repair has been considered an …
These results strongly support previous proposals that N-acetylcysteine can be useful in the treatment of early Alzheimer’s disease patients.
PMID: Front Aging Neurosci. 2018 ;10:399. Epub 2018 Dec 6. PMID: 30574085 Abstract Title: N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model. Abstract: We have previously reported that primary hippocampal neurons exposed to synaptotoxic amyloid beta oligomers (AβOs), which are likely causative agents of Alzheimer's …
Quercetin possibly possess the anti-diabetic retinopathy potential.
PMID: J Biochem. 2020 Jan 21. Epub 2020 Jan 21. PMID: 31960917 Abstract Title: Quercetin attenuates high glucose induced injury in human retinal pigment epithelial cell line ARPE-19 by up-regulation of miR-29b. Abstract: Quercetin is a kind of distinctive bioactive flavonoid that has potent anti-oxidant, anti-inflammatory and anti-diabetic properties. The present paper was designed to …
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Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway.
PMID: Biochem Biophys Res Commun. 2020 Jan 18. Epub 2020 Jan 18. PMID: 31964531 Abstract Title: Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway. Abstract: Cancer stem-like cells are rare immortal cells within tumor, which are thought to play important roles in ionizing radiation (IR) therapy-resistance. Quercetin is a natural …
Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats.
PMID: Int J Biol Macromol. 2019 Nov 9. Epub 2019 Nov 9. PMID: 31712153 Abstract Title: Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats. Abstract: Ganoderma lucidum polysaccharides (GLP), a kind of medicinal mushrooms, were widely used in southeastern countries with putative anti-diabetic effects. In order …
Anti-cancer effects of a neutral triterpene fraction from Ganoderma lucidum and its active constituents on SW620 human colorectal cancer cells.
PMID: Anticancer Agents Med Chem. 2019 Oct 14. Epub 2019 Oct 14. PMID: 31749435 Abstract Title: Anti-Cancer Effects of a Neutral Triterpene Fraction from Ganoderma lucidum and its Active Constituents on SW620 Human Colorectal Cancer Cells. Abstract: BACKGROUND: Ganoderma lucidum (Leyss. ex Fr.) Karst. (G. lucidum, GL) belongs to the family of Ganodermataceae (Basidiomycetes), and …
G. lucidum has been proved to exhibit significant role in preventing and treating various kidney diseases.
PMID: Adv Exp Med Biol. 2019 ;1182:243-262. PMID: 31777022 Abstract Title: Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Renal Diseases and Clinical Applications. Abstract: The mechanisms of kidney diseases, such as acute kidney injury (AKI) and chronic kidney disease (CKD), have been intensively studied. Nonetheless, the morbidity and mortality of AKI and CKD increased …
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