PMID: J Cell Mol Med. 2019 01 ;23(1):4-20. Epub 2018 Nov 15. PMID: 30444050 Abstract Title: Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China. Abstract: Poria cocos is an edible medicinal fungus known as"Fuling"in Chinese and has been used as a Chinese traditional medicine for more than two thousand …
Author Archives: Taylor Mercado
The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism.
PMID: Food Funct. 2018 Nov 14 ;9(11):5936-5949. PMID: 30378628 Abstract Title: The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism. Abstract: In this study, the protective effects of a carboxymethyl polysaccharide CMP33 from Poria cocos against inflammatory bowel disease (IBD) were investigated using TNBS-induced colitis in mice. The …
Phenolic rich Cocos nucifera inflorescence extract ameliorates inflammatory responses in LPS-stimulated RAW264.7 macrophages.
PMID: Inflammopharmacology. 2019 Jul 26. Epub 2019 Jul 26. PMID: 31350628 Abstract Title: Phenolic rich Cocos nucifera inflorescence extract ameliorates inflammatory responses in LPS-stimulated RAW264.7 macrophages and toxin-induced murine models. Abstract: Anti-inflammatory and antinociceptive effects of the acetone extract of Cocos nucifera (CnAE), an important ingredient in several traditional drugs, have been studied using different …
Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activation.
PMID: Anticancer Drugs. 2019 Oct 22. Epub 2019 Oct 22. PMID: 31651438 Abstract Title: Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activation. Abstract: We have previously demonstrated the pivotal role of Jnk-mediated Irf-3/c-Jun in regulating nuclear factor kappa-Β ligand (RANKL)-induced osteoclastogenesis. Here, we demonstrated that proanthocyanidins (PACs) target Irf-3 to alleviate breast cancer-induced …
Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm.
PMID: Epigenetics. 2018 ;13(10-11):1106-1126. Epub 2018 Nov 16. PMID: 30444163 Abstract Title: Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm. Abstract: All animals have body burdens of polychlorinated biphenyls (PCBs) despite their ban decades ago. These and modern endocrine-disrupting chemicals (EDCs) such as the fungicide vinclozolin …
Beta-sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells.
PMID: Nutr Cancer. 1998 ;32(1):8-12. PMID: 9824850 Abstract Title: beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Abstract: Epidemiological evidence has shown that men consuming a low-fat, high-fiber diet containing high amounts of plant products have a lower risk of prostate cancer than men consuming a Western diet. One …
Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake.
PMID: Biol Pharm Bull. 2008 Mar ;31(3):400-4. PMID: 18310900 Abstract Title: Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake. Abstract: To investigate chemopreventive effect of liposomal beta-sitosterol on tumor metastasis, we prepared liposomal beta-sitosterol composed of egg yolk phosphatidylcholine for oral delivery. Although orally administered beta-sitosterol (4 micromol as beta-sitosterol/mouse) was not absorbed into plasma, …
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Beta-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids.
PMID: Anticancer Res. 1996 Sep-Oct;16(5A):2797-804. PMID: 8917388 Abstract Title: beta-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Abstract: The purpose of the present study was to examine the effect of beta-sitosterol, the main dietary phytosterol on the growth of HT-29 cells, a human colon cancer cell line. In addition, the incorporation …
Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells.
PMID: Biochem Pharmacol. 2018 06 ;152:60-70. Epub 2018 Mar 17. PMID: 29559312 Abstract Title: Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells and xenograft mouse models. Abstract: We investigated the anti-cancer effects of beta-sitosterol (BS), a plant-derived sterol in AGS human gastric adenocarcinoma cells and xenograft mouse models. …
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