PMID: Environ Sci Pollut Res Int. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31889292 Abstract Title: Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats. Abstract: Liver injury is one of the adverse effects of methotrexate (MTX). Ferulic acid (FA) is an antioxidant phytochemical that confers …
Author Archives: Taylor Mercado
Astragaloside II alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo.
PMID: Am J Transl Res. 2019 ;11(11):7074-7083. Epub 2019 Nov 15. PMID: 31814910 Abstract Title: Astragaloside II alleviates the symptoms of experimental ulcerative colitisand. Abstract: BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory intestinal disease, and its morbidity is rising worldwide. Previous study indicated that astragaloside II (AS II), a monomeric compound, was used to …
The combination of astragaloside IV and ferulic acid is a promising candidate for the treatment of hepatic fibrosis.
PMID: Dig Dis Sci. 2020 Jan 3. Epub 2020 Jan 3. PMID: 31900718 Abstract Title: Astragaloside IV Synergizes with Ferulic Acid to Alleviate Hepatic Fibrosis in Bile Duct-Ligated Cirrhotic Rats. Abstract: BACKGROUND: Due to the multi-factorial etiology of hepatic fibrosis, multi-target therapeutics based on combinatory drugs is known to be a promising strategy for the …
Astragaloside IV protects ATDC5 cells from lipopolysaccharide-caused damage.
PMID: Pharm Biol. 2020 Dec ;58(1):89-97. PMID: 31906765 Abstract Title: Astragaloside IV protects ATDC5 cells from lipopolysaccharide-caused damage through regulating miR-203/MyD88. Abstract: Osteoarthritis (OA) is a degenerative arthrosis sickness. Astragaloside IV (AS-IV) functions by relieving inflammatory damage.We aimed to investigate the mechanism by which AS-IV protects ATD cells from lipopolysaccharide (LPS)-induced damage.ATDC5 cells were transfected …
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Astragaloside IV ameliorates intermittent hypoxia-induced inflammatory dysfunction.
PMID: Sleep Breath. 2020 Jan 6. Epub 2020 Jan 6. PMID: 31907823 Abstract Title: Astragaloside IV ameliorates intermittent hypoxia-induced inflammatory dysfunction by suppressing MAPK/NF-κB signalling pathways in Beas-2B cells. Abstract: PURPOSE: Intermittent hypoxia is a characteristic pathological change in obstructive sleep apnoea (OSA) that can initiate oxidative stress reaction and pro-inflammatory cytokine release. The purpose …
A combination of doxorubicin and tetrahydrocurcumin nanoparticles is a promising strategy for synergistic and sensitizing chemoradiotherapy of glioma.
PMID: Med Sci Monit. 2019 Dec 19 ;25:9737-9751. Epub 2019 Dec 19. PMID: 31856143 Abstract Title: Multifunctional Polyethylene Glycol (PEG)-Poly (Lactic-Co-Glycolic Acid) (PLGA)-Based Nanoparticles Loading Doxorubicin and Tetrahydrocurcumin for Combined Chemoradiotherapy of Glioma. Abstract: BACKGROUND This study aimed to prepare doxorubicin- and tetrahydrocurcumin-loaded and transferrin-modified PEG-PLGA nanoparticles (Tf-NPs-DOX-THC) for enhanced and synergistic chemoradiotherapy. MATERIAL AND …
At-Home Pelvic Floor Therapy: How to Do Pelvic Floor Exercises
If you have symptoms of pelvic floor disorders such as urinary incontinence, pelvic organ prolapse, painful sexual intercourse or pelvic pain, learning how to do pelvic floor exercises in the comfort of your home could help you avoid surgery, relieve symptoms and regain your quality of life. read more
Magnolol-enhanced the therapeutic effect of sorafenib in liver cancer.
PMID: Cancers (Basel). 2019 Dec 30 ;12(1). Epub 2019 Dec 30. PMID: 31905887 Abstract Title: Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo. Abstract: Although sorafenib, an oral multikinase inhibitor, was approved as a treatment drug of advance hepatocellular carcinoma (HCC), treatment efficacy …
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Magnolol alleviates IL-1β-induced dysfunction of chondrocytes.
PMID: J Interferon Cytokine Res. 2020 Jan 9. Epub 2020 Jan 9. PMID: 31916911 Abstract Title: Magnolol Alleviates IL-1β-Induced Dysfunction of Chondrocytes Through Repression of SIRT1/AMPK/PGC-1α Signaling Pathway. Abstract: Osteoarthritis is a common chronic joint disease related with mitochondrial dysfunction, damage, and synthetic defects in chondrocytes. Magnolol is a lignin extracted fromwith antioxidant and anti-inflammation …
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Magnolol might be used as a potential treatment for alcoholic liver damage.
PMID: Front Pharmacol. 2019 ;10:1459. Epub 2019 Dec 5. PMID: 31920652 Abstract Title: Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway. Abstract: Alcoholic liver damage (ALD) is a toxic liver damage caused by excessive drinking. Oxidative stress is one of the most crucial pathogenic factors leading to ALD. Magnolol …
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