PMID: Am J Transl Res. 2019 ;11(12):7579-7590. Epub 2019 Dec 15. PMID: 31934302 Abstract Title: Paeoniflorin exhibits antitumor effects in nasopharyngeal carcinoma cells through downregulation of NEDD4. Abstract: Paeoniflorin (PF), which is isolated from the paeony root, possesses tumor suppressive function in a variety of malignancies. However, it is unknown whether PF possesses anticancer activity …
Author Archives: Taylor Mercado
Nobiletin reversed paclitaxel resistance in multi-drug resistance tumors.
PMID: Phytomedicine. 2019 Nov 26 ;67:153141. Epub 2019 Nov 26. PMID: 31884406 Abstract Title: Nobiletin potentiates paclitaxel anticancer efficacy in A549/T xenograft model: Pharmacokinetic and pharmacological study. Abstract: BACKGROUND: Nobiletin (N), a polymethoxylated flavone from citrus fruits, enhanced anti-cancer effects of paclitaxel (PTX) in multi-drug resistance (MDR) cancer cells via inhibiting P-glycoprotein (P-gp) in our …
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Nobiletin inhibits HBsAg production and hepatitis B virus replication.
PMID: Biochem Biophys Res Commun. 2020 Jan 15. Epub 2020 Jan 15. PMID: 31954513 Abstract Title: Nobiletin, a novel inhibitor, inhibits HBsAg production and hepatitis B virus replication. Abstract: Chronic hepatitis B virus (HBV) infection is a serious problem due to its extensive worldwide distribution and poor prognosis including cirrhosis and/or hepatocellular carcinoma. The hepatitis …
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Vitex rotundifolia fractions induced apoptosis in human breast cancer T-47D cell line.
PMID: Asian Pac J Cancer Prev. 2019 Dec 1 ;20(12):3555-3562. Epub 2019 Dec 1. PMID: 31870094 Abstract Title: Vitex Rotundifolia Fractions Induced Apoptosis in Human Breast Cancer T-47D Cell Line via Activation of Extrinsic and Intrinsic Pathway. Abstract: OBJECTIVE: Breast cancer is the most frequently diagnosed cancer worldwide. The main objective of the present study …
Anti-atherosclerotic effects of fruits of Vitex rotundifolia.
PMID: Biomolecules. 2019 Nov 12 ;9(11). Epub 2019 Nov 12. PMID: 31726713 Abstract Title: Anti-Atherosclerotic Effects of Fruits ofand Their Isolated Compounds via Inhibition of Human LDL and HDL Oxidation. Abstract: Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) oxidation are well known to increase the risk for atherosclerosis. In our ongoing research on natural products …
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Hesperidin improves insulin resistance via down-regulation of inflammatory responses.
PMID: PLoS One. 2020 ;15(1):e0227637. Epub 2020 Jan 13. PMID: 31929574 Abstract Title: Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation. Abstract: Leptin resistance and co-existing insulin resistance is considered as hallmark of diet-induced obesity. Here, we investigated therapeutic potential of hesperidin to improve leptin and insulin resistance …
Hesperidin significantly suppresses cell migration of MDA-MB231 cells.
PMID: Molecules. 2020 Jan 8 ;25(2). Epub 2020 Jan 8. PMID: 31936263 Abstract Title: Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer. Abstract: Programmed death ligand 1 (PD-L1) is overexpressed in the most aggressive breast cancer subtype, triple-negative breast cancer (TNBC), assisting the eradication of antitumor immunity, and …
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A review of the benefits of hesperidin in central nervous system disorders.
PMID: Anat Cell Biol. 2019 Dec ;52(4):369-377. Epub 2019 Dec 31. PMID: 31949974 Abstract Title: Benefits of hesperidin in central nervous system disorders: a review. Abstract: Citrus species contain significant amounts of flavonoids that possess antioxidant activities; furthermore, dietary citrus is not associated with adverse effects or cytotoxicity in healthy individuals. Hesperidin, which is an …
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Antiviral activity of four types of bioflavonoid against dengue virus type-2.
PMID: Virol J. 2011 Dec 28 ;8:560. Epub 2011 Dec 28. PMID: 22201648 Abstract Title: Antiviral activity of four types of bioflavonoid against dengue virus type-2. Abstract: BACKGROUND: Dengue is a major mosquito-borne disease currently with no effective antiviral or vaccine available. Effort to find antivirals for it has focused on bioflavonoids, a plant-derived polyphenolic …
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These findings demonstrated the potential of mushroom extracts as anti-dengue therapeutic agents with less toxic effects.
PMID: BMC Complement Altern Med. 2019 Sep 18 ;19(1):260. Epub 2019 Sep 18. PMID: 31533688 Abstract Title: Anti-viral activity of culinary and medicinal mushroom extracts against dengue virus serotype 2: an in-vitro study. Abstract: BACKGROUND: Dengue is a mosquito-borne viral infection that has become a major public health concern worldwide. Presently, there is no specific …
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