PMID: Biochimie. 2020 Jan ;168:10-16. Epub 2019 Oct 25. PMID: 31669604 Abstract Title: Pelargonidin ameliorates acetaminophen-induced hepatotoxicity in mice by inhibiting the ROS-induced inflammatory apoptotic response. Abstract: The common analgesic acetaminophen (N-acetyl-p-aminophenol, APAP) is non-toxic to the liver at therapeutic doses. However, an overdose of APAP can lead to APAP-induced liver failure, which has emerged …
Author Archives: Taylor Mercado
Pelargonidin 3-glucoside-enriched strawberry attenuates symptoms of DSS-induced inflammatory bowel disease.
PMID: Eur J Nutr. 2019 Nov 7. Epub 2019 Nov 7. PMID: 31696323 Abstract Title: Pelargonidin 3-glucoside-enriched strawberry attenuates symptoms of DSS-induced inflammatory bowel disease and diet-induced metabolic syndrome in rats. Abstract: PURPOSE: To determine whether the anthocyanin, pelargonidin 3-glucoside (P3G), attenuates symptoms of inflammatory bowel disease (IBD) and metabolic syndrome in rats.METHODS: We tested …
Galbanic acid enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus.
PMID: Biol Pharm Bull. 2007 Sep ;30(9):1805-7. PMID: 17827745 Abstract Title: Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus. Abstract: In this study the enhancement effect of Ferula szowitsiana roots' acetone extract on the antibacterial activity of penicillin G and cephalexin was evaluated against Staphylococcus aureus. …
Effect of galbanic acid in resistant clinical isolates of Staphylococcus aureus.
PMID: Braz J Microbiol. 2010 Jul ;41(3):574-80. Epub 2010 Sep 1. PMID: 24031531 Abstract Title: Effect of galbanic Acid, a sesquiterpene coumarin from ferula szowitsiana, as an inhibitor of efflux mechanism in resistant clinical isolates of Staphylococcus aureus. Abstract: Galbanic acid, a sesquiterpene coumarin from Ferula szowitsiana roots, was investigated for its potentiating effect on …
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Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation.
PMID: Pharm Res. 2011 Mar ;28(3):597-609. Epub 2010 Nov 10. PMID: 21063754 Abstract Title: Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation. Abstract: PURPOSE: To investigate whether galbanic acid (GBA) exerts anti-angiogenic and anti-cancer activities.METHODS: Using human umbilical vein endothelial cell (HUVEC) model, we analyzed effects …
Galbanic acid decreases androgen receptor abundance and signaling and induces G1 arrest in prostate cancer cells.
PMID: Int J Cancer. 2012 Jan 1 ;130(1):200-12. Epub 2011 May 9. PMID: 21328348 Abstract Title: Galbanic acid decreases androgen receptor abundance and signaling and induces G1 arrest in prostate cancer cells. Abstract: Androgen receptor (AR) signaling is crucial for the genesis and progression of prostate cancer (PCa). We compared the growth responses of AR(+) …
Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells.
PMID: Fitoterapia. 2015 Mar ;101:1-11. Epub 2014 Dec 13. PMID: 25510323 Abstract Title: Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells. Abstract: Hypoxia Inducible Factor-1 plays a key transcriptional role in the adaptation of hypoxic solid tumors to low oxygen environment. Here, we aimed to investigate galbanic acid (GBA) inhibitory effects on …
Continue reading “Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells.”
These findings suggest that galbanic acid induces apoptosis in H460 cells.
PMID: Phytother Res. 2015 Jun ;29(6):844-9. Epub 2015 Mar 6. PMID: 25753585 Abstract Title: Apoptotic Effect of Galbanic Acid via Activation of Caspases and Inhibition of Mcl-1 in H460 Non-Small Lung Carcinoma Cells. Abstract: Galbanic acid (GBA), a major compound of Ferula assafoetida, was known to have cytotoxic, anti-angiogenic and apoptotic effects in prostate cancer …
Continue reading “These findings suggest that galbanic acid induces apoptosis in H460 cells.”
Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells.
PMID: Eur J Pharmacol. 2019 Mar 15 ;847:91-96. Epub 2019 Jan 25. PMID: 30689998 Abstract Title: Galbanic acid potentiates TRAIL induced apoptosis in resistant non-small cell lung cancer cells via inhibition of MDR1 and activation of caspases and DR5. Abstract: Galbanic acid (GBA) is known a sesquiterpene coumarin to have apoptotic, anti-hypoxic, anti-proliferative, anti-hepatitis, anti-angiogenic, …
Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells.
PMID: Avicenna J Phytomed. 2019 May-Jun;9(3):237-247. PMID: 31143691 Abstract Title: Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells. Abstract: Objective: In the current investigation, we aimed to study the combined cytotoxicity of curcumin, as a nanomicellar formulation, and galbanic acid (Gal), dissolved in DMSO …
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