A case series of multiple sclerosis-like persistent inflammatory activity and encephalitis in the brain of hepatitis B vaccinees.

PMID:  Neurology. 1999 Jul 22 ;53(2):396-401. PMID: 10430433 Abstract Title:  Encephalitis after hepatitis B vaccination: recurrent disseminated encephalitis or MS? Abstract:  OBJECTIVE: To describe clinical and MRI features of patients with a disease suggestive of CNS inflammation after hepatitis B vaccination.METHODS: Eight patients with confirmed CNS inflammation occurring less than 10 weeks after hepatitis B …

This review indicates that molecular similarity between the hepatitis B antigens and myelin proteins could explain neurological events following hepatitis B vaccination.

PMID:  Rev Neurol (Paris). 2001 Sep ;157(8-9 Pt 2):929-34. PMID: 11787357 Abstract Title:  [Borderline forms of multiple sclerosis]. Abstract:  Multiple sclerosis (MS) has been described for more than a century, but its cause remains unknown and no simple diagnostic marker is available. Therefore, it is not surprising that numerous articles were written on closely related …

This study could not rule out a moderate increased risk of a central nervous system demyelinating event following hepatitis B vaccination in adults.

PMID:  Neuroepidemiology. 2002 Jul-Aug;21(4):180-6. PMID: 12065880 Abstract Title:  Hepatitis B vaccination and first central nervous system demyelinating event: a case-control study. Abstract:  OBJECTIVE: To investigate the relationship between hepatitis B (HB) vaccination and a first central nervous system (CNS) demyelinating event in adults.METHODS: In 1998, we conducted a multicentre, hospital-based case-control study which enrolled 402 …

Clinically apparent chickenpox is associated with a lower risk of childhood-onset multiple sclerosis.

PMID:  Am J Epidemiol. 2009 May 15 ;169(10):1260-6. Epub 2009 Mar 27. PMID: 19329530 Abstract Title:  Clinically observed chickenpox and the risk of childhood-onset multiple sclerosis. Abstract:  The authors conducted a population-based case-control study to investigate whether clinically observed chickenpox, linked with a level of intensity for clinical expression, increases the risk of multiple sclerosis …

Acute disseminated myelitis is a monophasic inflammatory demyelinating disorder with aggressive neurological deficits that usually follows viral infection or immunization.

PMID:  PLoS One. 2011 ;6(8):e22766. Epub 2011 Aug 10. PMID: 21853047 Abstract Title:  Comparative brain stem lesions on MRI of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis. Abstract:  BACKGROUND: Brain stem lesions are common in patients with acute disseminated encephalomyelitis (ADEM), neuromyelitis optica (NMO), and multiple sclerosis (MS).OBJECTIVES: To investigate comparative brain stem lesions …

Polysorbate 80 can have profound effects on cardiac dynamics.

PMID:  Am J Physiol. 1977 Mar ;232(3):H331-4. PMID: 842689 Abstract Title:  Cardiovascular effects of radioactive microsphere suspensions and Tween 80 solutions. Abstract:  The cardiovascular effects of two concentrations of Tween 80 (polyoxyethylene sorbitan mono-oleate), a surface-active agent commonly used to prevent aggregation of radionuclide-labeled microspheres, were examined in conscious dogs. Two types of adverse reactions …

Polysorbate 80 causes serious side effects in oral medications.

PMID:  Anticancer Drugs. 2007 Feb ;18(2):95-103. PMID: 17159596 Abstract Title:  Alternative drug formulations of docetaxel: a review. Abstract:  The anticancer drug docetaxel (Taxotere) is formulated in the nonionic surfactant polysorbate 80 (Tween 80). Early in the clinical development of docetaxel, it became clear that docetaxel administration is associated with the occurrence of unpredictable (acute) hypersensitivity …

Pregnant rats fed poylsorbate 80 produced offspring with a low birth weight.

PMID:  Reprod Toxicol. 2008 Jan ;25(1):89-99. Epub 2007 Aug 25. PMID: 17961976 Abstract Title:  Evaluation of developmental neurotoxicity of polysorbate 80 in rats. Abstract:  The developmental neurotoxicity of polysorbate 80 (PS80) was evaluated in rats. Crl:CD(SD) rats were given drinking water containing PS80 at 0, 0.018, 0.13, 1.0, or 7.5% (0, 0.035, 0.245, 1.864, or …

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