PMID: J Ethnopharmacol. 2020 Jan 6:112548. Epub 2020 Jan 6. PMID: 31917277 Abstract Title: Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Lychee seed, the seed of Litchi chinensis Sonn. is one of the commonly used in traditional Chinese medicine (TCM). It possesses …
Author Archives: Taylor Mercado
Naringenin attenuates nonalocholic fatty liver disease.
PMID: Br J Pharmacol. 2019 Nov 23. Epub 2019 Nov 23. PMID: 31758699 Abstract Title: Naringenin attenuates nonalocholic fatty liver disease by downregulating NLRP3/NF-κB pathway in mice. Abstract: BACKGROUND AND PURPOSE: Our previous study demonstrate that Naringenin (NGN), a flavonoid compound with strong anti-inflammatory activity, could attenuate nonalcoholic fatty liver disease (NAFLD) induced by a …
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Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation.
PMID: Naunyn Schmiedebergs Arch Pharmacol. 2019 Nov 22. Epub 2019 Nov 22. PMID: 31758207 Abstract Title: Protective effect of apigenin on d-galactosamine/LPS-induced hepatocellular injury by increment of Nrf-2 nucleus translocation. Abstract: Apigenin has a protective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced mouse liver injury through the increments of hepatic nuclear factor erythroid 2-related factor 2 (Nrf-2) …
Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity.
PMID: Pharmacol Res. 2019 Dec 23 ;152:104586. Epub 2019 Dec 23. PMID: 31877350 Abstract Title: Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity. Abstract: Visceral obesity is the excess deposition of visceral fat within the abdominal cavity that surrounds vital organs. Visceral obesity is directly associated with metabolic syndrome, breast cancer and endometrial cancer. …
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Rosmarinic acid may help preserve adipose tissue-derived stem cells survival after they are transplanted into ischemic organs.
PMID: Prev Nutr Food Sci. 2019 Dec ;24(4):449-455. Epub 2019 Dec 31. PMID: 31915641 Abstract Title: Rosmarinic Acid Protects Adipose Tissue-Derived Mesenchymal Stem Cells in Nutrient-Deficient Conditions. Abstract: One of the major challenges for stem cell therapy of ischemic organs is that the transplanted cells are confronted with nutrient deficiency and oxidative stress. Previous studies …
EGCG transiently inhibits both cell proliferation and migration of oral cavity cancer cells.
PMID: J Oral Pathol Med. 2019 Aug ;48(7):604-610. Epub 2019 Jun 28. PMID: 31188490 Abstract Title: Functional and molecular effects of a green tea constituent on oral cancer cells. Abstract: BACKGROUND: Green tea is heavily consumed on a global basis for its health benefits. The active ingredient, (-)-epigallocatechin gallate (EGCG), is a major polyphenol demonstrated …
Garlic and allopurinol attenuate hepatic apoptosis induced by fipronil in male albino rats.
n/a PMID: Regul Toxicol Pharmacol. 2019 Oct ;107:104400. Epub 2019 May 29. PMID: 31152858 Abstract Title: Garlic and allopurinol attenuate hepatic apoptosis induced by fipronil in male albino rats. Abstract: Fipronil (FPN) can induce oxidative tissue damage and may be contemplated as an apoptosis inducer. Our aim is to investigate the possible hepatoprotective roles of …
Whole garlic supplementation could meliorate the high fat diet-induced dyslipidemia and disturbance of gut microbiome.
PMID: Nutrients. 2019 May 29 ;11(6). Epub 2019 May 29. PMID: 31146458 Abstract Title: Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis. Abstract: Garlic (L.) contains prebiotic components, fructans, antibacterial compounds, and organosulfur compounds. The complex ingredients of garlic seem to impart a paradoxical result on the gut microbiome. In this …
Intranasally administered viral-based vaccines can transfer genes to the olfactory bulb.
PMID: Genet Vaccines Ther. 2008 Feb 8 ;6:5. Epub 2008 Feb 8. PMID: 18261231 Abstract Title: Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector. Abstract: It is believed that respiratory mucosal immunization triggers more effective immune protection than parenteral immunization against respiratory infection caused by viruses and …
This influenza A vaccine did not boost T cell responses in adults.
PMID: Clin Infect Dis. 2011 Jan 1 ;52(1):1-7. PMID: 21148512 Abstract Title: Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1. Abstract: BACKGROUND: Influenza A viruses cause occasional pandemics and frequent epidemics. Licensed influenza vaccines that induce high antibody titers to the highly polymorphic viral surface antigen hemagglutinin must be …
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