Strategies to enhance intranasal flu vaccine effectiveness still pose a risk of viral mutation back to the pandemic strain.

PMID:  PLoS One. 2011 ;6(5):e19863. Epub 2011 May 20. PMID: 21625486 Abstract Title:  Intranasal immunization with recombinant HA and mast cell activator C48/80 elicits protective immunity against 2009 pandemic H1N1 influenza in mice. Abstract:  BACKGROUND: Pandemic influenza represents a major threat to global health. Vaccination is the most economic and effective strategy to control influenza …

The live attentuated influenza vaccine can alter bacterial transmigration towards the middle ear and increase the risk of otitis media. This risk was not clinically investigated before the implementation of the vaccine.

PMID:  J Infect Dis. 2015 Jul 15 ;212(2):195-201. Epub 2014 Dec 11. PMID: 25505300 Abstract Title:  Live attenuated influenza virus increases pneumococcal translocation and persistence within the middle ear. Abstract:  BACKGROUND: Infection with influenza A virus (IAV) increases susceptibility to respiratory bacterial infections, resulting in increased bacterial carriage and complications such acute otitis media, pneumonia, …

Guillain-Barre Syndrome may occur as a result of molecular mimicry.

PMID:  Neurol Neurochir Pol. 2005 May-Jun;39(3):230-6. PMID: 15981163 Abstract Title:  [Guillain-Barré Syndrome and its association with infectious factors]. Abstract:  Guillain-Barré Syndrome (GBS) is an acute polyneuropathy often triggered by inflammatory and probably autoimmune mechanisms. Development of GBS is in 2/3 of cases preceded by acute infection, typically with gastrointestinal or respiratory symptoms. Infectious agents related …

A case report of anaphylaxis following influenza vaccination, attributed to the gelatin and ovalbumin in the vaccine.

PMID:  Int Arch Allergy Immunol. 2008 ;146(1):85-8. Epub 2007 Dec 14. PMID: 18087166 Abstract Title:  Anaphylaxis from the influenza virus vaccine. Abstract:  BACKGROUND: Allergic reactions to the influenza vaccine are uncommon and usually associated with sensitivity to egg or gelatin. The aim of this study was to report the case of anaphylaxis to the influenza …

Guillain-Barre syndrome can be induced by vaccination or infection.

PMID:  Clin Rev Allergy Immunol. 2012 Apr ;42(2):121-30. PMID: 20890797 Abstract Title:  Guillain-Barré syndrome–a classical autoimmune disease triggered by infection or vaccination. Abstract:  Guillain-Barré syndrome (GBS) is a rare autoimmune disorder, the incidence of which is estimated to be 0.6-4/100,000 person/year worldwide. Often, GBS occurs a few days or weeks after the patient has had …

Influenza vaccines contain measurable quantities of residual egg white protein.

PMID:  Pediatr Clin North Am. 2011 Apr ;58(2):427-43, xi. PMID: 21453811 Abstract Title:  Current understanding of egg allergy. Abstract:  Egg is one of the most important allergens in childhood feeding, and egg allergy can pose quality-of-life concerns. A clear clinical history and the detection of egg white-specific immunoglobulin E (IgE) will confirm the diagnosis of …

The respiratory syncytial virus live vaccine is ineffective in infants younger than 4 months.

PMID:  Vaccine. 2014 Aug 20 ;32(37):4726-9. Epub 2014 Jul 6. PMID: 25005882 Abstract Title:  The association between age and the development of respiratory syncytial virus neutralising antibody responses following natural infection in infants. Abstract:  To determine the age at which infants mount significant neutralising antibody responses to both natural RSV infection and live vaccines that …

A case report of aluminum granuloma after DTaP-IPV vaccination.

PMID:  Pediatr Dermatol. 2019 Jan ;36(1):e17-e19. Epub 2018 Nov 28. PMID: 30488642 Abstract Title:  Aluminum granuloma in a child secondary to DTaP-IPV vaccination: A case report. Abstract:  Reports detailing the acute formation of aluminum granulomas, which can cause persistent, intensely pruritic nodules secondary to the administration of aluminum-containing vaccines, are infrequently described in medical literature. …

A case report of acute cerebellar ataxia after hepatitis B vaccination.

PMID:  Acta Neurol Scand. 1994 Jun ;89(6):462-3. PMID: 7976236 Abstract Title:  Acute cerebellar ataxia after immunisation with recombinant hepatitis B vaccine. Abstract:  We report one woman with acute cerebellar ataxia (ACA), a well-defined clinical syndrome, which occurred 10 days after the second vaccination with recombinant hepatitis B vaccine. The patient had no previous symptoms or …

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