PMID: Int J Pharm. 2019 Nov 25 ;571:118751. Epub 2019 Oct 9. PMID: 31605722 Abstract Title: Doxorubicin combined with betulinic acid or lonidamine in RGD ligand-targeted pH-sensitive micellar system for ovarian cancer treatment. Abstract: Synergistic combination therapy involving the integration of chemotherapeutics and chemosensitizers into micelles has demonstrated great potential for tumor-specific location release. Here, …
Author Archives: Taylor Mercado
Betulinic acid is a safe and effective herbal medicine compound that can be used for the prevention of hepatocellular carcinoma growth.
PMID: Am J Transl Res. 2019 ;11(11):6952-6964. Epub 2019 Nov 15. PMID: 31814899 Abstract Title: Betulinic acid induces autophagy-mediated apoptosis through suppression of the PI3K/AKT/mTOR signaling pathway and inhibits hepatocellular carcinoma. Abstract: Betulinic acid (BA) is a pentacyclic triterpenoid compound that widely exists in Chinese herbal medicine, and it has remarkable biological activity. However, the …
Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis.
PMID: Artif Cells Nanomed Biotechnol. 2018 ;46(sup1):324-335. Epub 2018 Jan 9. PMID: 29316822 Abstract Title: Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis rats. Abstract: Paeonol, as the main phenolic compound isolated from the Chinese herbs, has been confirmed to present anti-inflammatory effects on ulcerative colitis (UC) in our previous study. …
Paeonol represents a potential novel therapeutic approach for the treatment of pulmonary hypertension.
PMID: Eur J Pharmacol. 2018 Sep 5 ;834:257-265. Epub 2018 Jul 25. PMID: 30053410 Abstract Title: Paeonol regulates hypoxia-induced proliferation of pulmonary artery smooth muscle cells via EKR 1/2 signalling. Abstract: Pulmonary hypertension (PH) is a disease with a developmental origin characterized by obstructive vascular remodelling that is partially due to excessive pulmonary arterial smooth …
Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model.
PMID: J Cell Physiol. 2019 Aug ;234(8):14351-14363. Epub 2019 Feb 4. PMID: 30714138 Abstract Title: Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model. Abstract: Renal interstitial fibrosis (RIF) is a common manifestation of inflammatory and noninflammatory renal diseases, which correlates to renal excretory dysfunction. Recently, the long …
Declines in long-term subjective health were associated with receipt of anthrax vaccine by Gulf War veterans but not for those who did not deploy to the Gulf
PMID: Psychol Rep. 2002 Apr ;90(2):639-53. PMID: 12061608 Abstract Title: Self-reported changes in subjective health and anthrax vaccination as reported by over 900 Persian Gulf War era veterans. Abstract: A 1999 study of United Kingdom servicemembers by Unwin, et al. recently found significant relationships between anthrax and other vaccinations, reactions to those vaccines, and later …
Paeonol: pharmacological effects and mechanisms of action.
PMID: Int Immunopharmacol. 2019 Jul ;72:413-421. Epub 2019 Apr 25. PMID: 31030097 Abstract Title: Paeonol: pharmacological effects and mechanisms of action. Abstract: Paeonia suffruticosa possesses various medicinal benefits and has been used extensively in traditional oriental medicine for thousands of years. Paeonol is the main component isolated from the root bark of Paeonia suffruticosa. The …
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The most common serious adverse events reported with the trivalent influenza vaccine was fevers and seizures.
PMID: Vaccine. 2009 Jul 9 ;27(32):4278-83. Epub 2009 May 28. PMID: 19450636 Abstract Title: Serious adverse events rarely reported after trivalent inactivated influenza vaccine (TIV) in children 6-23 months of age. Abstract: In October 2003 the Advisory Committee on Immunization Practices (ACIP) recommended influenza vaccination for all children ages 6-23 months. We evaluated the safety …
The Apoptotic and Anticancer Effects of Cinnamon
Cinnamon’s anticancer effects are well examined, but recent research suggests that the active ingredients in cinnamon have additional apoptotic effects on cancerous cells
Protection of paeonol against epirubicin-induced hepatotoxicity.
PMID: Biosci Trends. 2019 Jul 22 ;13(3):253-260. Epub 2019 Jun 23. PMID: 31231109 Abstract Title: Protection of paeonol against epirubicin-induced hepatotoxicity: A metabolomic study. Abstract: Paeonol extracted from the Moutan Cortex, possesses hepatoprotective activity against epirubicin (EPI)-induced liver damage. This study evaluated the protective effect of paeonol on EPI-induced hepatotoxicity and explored the underlying metabolomic …
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