Taylor Mercado

Lycium barbarum polysaccharides attenuate kidney injury in sepsis.

PMID: Life Sci. 2019 Dec 28:117240. Epub 2019 Dec 28. PMID: 31891722 Abstract Title: Lycium barbarum polysaccharides attenuate kidney injury in septic rats by regulating Keap1-Nrf2/ARE pathway. Abstract: Lycium barbarum polysaccharides (LBP) are derived from Wolfberry and have antioxidant activities. This study aimed to evaluate the efficacy of LBP for kidney injury in a rat …

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Piperlongumine induces apoptosis in hepatocellular carcinoma cells by ROS-mediated ER stress.

PMID: Front Pharmacol. 2019 ;10:1180. Epub 2019 Oct 14. PMID: 31680962 Abstract Title: Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress. Abstract: Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related deaths globally. Despite advances in diagnosis and treatment, the incidence …

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Piperlongumine inhibits Akt phosphorylation to reverse resistance to cisplatin in human non-small cell lung cancer cells.

PMID: Front Pharmacol. 2019 ;10:1178. Epub 2019 Oct 11. PMID: 31680961 Abstract Title: Piperlongumine Inhibits Akt Phosphorylation to Reverse Resistance to Cisplatin in Human Non-Small Cell Lung Cancer CellsROS Regulation. Abstract: Resistance is a major concern when administering chemotherapy to patients with non-small cell lung cancer (NSCLC). Chemosensitizer are agents that can reverse resistance to …

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Piperlongumine exerts anticancer effects in ER-positive breast cancer cells by inhibiting cell proliferation and migration.

PMID: Antioxidants (Basel). 2019 Nov 14 ;8(11). Epub 2019 Nov 14. PMID: 31739520 Abstract Title: Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells. Abstract: Piperlongumine (PL), a natural product derived from long pepper (Piper longum L.), is known to exhibit anticancer effects. However, the effect …

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Sulforaphane protects cells against lipopolysaccharide-stimulated inflammation in murine macrophages.

PMID: Antioxidants (Basel). 2019 Nov 21 ;8(12). Epub 2019 Nov 21. PMID: 31766492 Abstract Title: Sulforaphane Protects Cells against Lipopolysaccharide-Stimulated Inflammation in Murine Macrophages. Abstract: Inflammation is an essential part for the general or innate immune defenses to defend against tissue damage and accelerate the curing process by providing protection against pathogens. Sulforaphane (SFN) is …

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Consumption of β-carotene-enriched foods could decrease the incidence of H. pylori-associated gastric disorders.

PMID: Antioxidants (Basel). 2019 Dec 11 ;8(12). Epub 2019 Dec 11. PMID: 31835889 Abstract Title: Inhibitory Effect ofβ-Carotene on-Induced TRAF Expression and Hyper-Proliferation in Gastric Epithelial Cells. Abstract: infection causes the hyper-proliferation of gastric epithelial cells that leads to the development of gastric cancer. Overexpression of tumor necrosis factor receptor associated factor (TRAF) is shown …

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DIM may ameliorate hyperglycemia and diabetic nephropathy.

PMID: Molecules. 2019 Dec 6 ;24(24). Epub 2019 Dec 6. PMID: 31817632 Abstract Title: Amelioration of Hyperglycemia-Induced Nephropathy by 3,3'-Diindolylmethane in Diabetic Mice. Abstract: Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. Diabetic nephropathy is a major complication of hyperglycemia. 3,3'-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found …

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DIM attenuated memory impairment by protecting hippocampal neuronal cells against oxidative damage.

PMID: Antioxidants (Basel). 2019 Dec 18 ;9(1). Epub 2019 Dec 18. PMID: 31861353 Abstract Title: 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Abstract: 3,3'-Diindolylmethane (DIM), a metabolite of indole-3-carbinol present in Brassicaceae vegetables, possesses various health-promoting effects. Nonetheless, the effect of …

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Piceatannol is a potent antioxidant in low concentrations with cytoprotective capacity.

PMID: Antioxidants (Basel). 2019 Dec 23 ;9(1). Epub 2019 Dec 23. PMID: 31878036 Abstract Title: Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress. Abstract: Piceatannol is a resveratrol metabolite that is considered a potent antioxidant and cytoprotector because of its high capacity to chelate/sequester reactive oxygen species. …

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Administration of Pycnogenol leads in improvement of erectile function in patients with diabetes.

PMID: Bratisl Lek Listy. 2019 ;120(12):941-944. PMID: 31855055 Abstract Title: Natural polyphenols improve erectile function and lipid profile in patients suffering from erectile dysfunction. Abstract: OBJECTIVES: Erectile dysfunction (ED) is characterised as the inability to achieve or maintain an erection to complete sexual intercourse. ED may be considered as an early complication of diabetes mellitus …

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