PMID: Bioengineered. 2019 12 ;10(1):172-181. PMID: 31034353 Abstract Title: Tetramethylpyrazine (TMP) protects rats against acute pancreatitis through NF-κB pathway. Abstract: Acute pancreatitis (AP) is a digestive disease characterized by pancreatic inflammation. Tetramethylpyrazine (TMP) has been effectively used to ameliorate the damage on intestinal mucosa injury in rats with acute necrotizing pancreatitis (ANP). We aim to …
Author Archives: Taylor Mercado
Tetramethylpyrazine alleviates LPS-induced inflammatory injury in HUVECs.
PMID: Biochem Biophys Res Commun. 2019 Jun 18 ;514(1):329-335. Epub 2019 Apr 26. PMID: 31036319 Abstract Title: Tetramethylpyrazine alleviates LPS-induced inflammatory injury in HUVECs by inhibiting Rho/ROCK pathway. Abstract: Endothelial dysfunction plays an important role in the pathogenesis of acute lung injury (ALI). Tetramethylpyrazine (TMP) has been reported to attenuate harmful changes in ALI rats. …
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Tetramethylpyrazine guards against cisplatin-induced nephrotoxicity.
PMID: Eur J Pharmacol. 2019 Aug 15 ;857:172422. Epub 2019 May 30. PMID: 31152701 Abstract Title: Tetramethylpyrazine guards against cisplatin-induced nephrotoxicity in rats through inhibiting HMGB1/TLR4/NF-κB and activating Nrf2 and PPAR-γ signaling pathways. Abstract: Cisplatin-induced acute renal injury is the most common and serious side effect, sometimes requiring discontinuation of the treatment. Thus, the development …
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Tetramethylpyrazine treatment may significantly delay mesenchymal stem cell senescence by suppressing NF-κB signalling.
PMID: Biosci Rep. 2019 Jun 28 ;39(6). Epub 2019 Jun 25. PMID: 31171713 Abstract Title: Anti-aging effects exerted by Tetramethylpyrazine enhances self-renewal and neuronal differentiation of rat bMSCs by suppressing NF-kB signaling. Abstract: In order to improve the therapeutic effects of mesenchymal stem cell (MSC)-based therapies for a number of intractable neurological disorders, a more …
Tetramethylpyrazine may be considered as a candidate therapeutic agent for the prevention and treatment of glaucoma.
PMID: Int J Mol Med. 2019 Aug ;44(2):503-512. Epub 2019 May 29. PMID: 31173163 Abstract Title: Tetramethylpyrazine protects retinal ganglion cells against H2O2‑induced damage via the microRNA‑182/mitochondrial pathway. Abstract: Glaucoma is the leading cause of irreversible blindness worldwide; the apoptosis of the retinal ganglion cells (RGCs) is a hallmark of glaucoma. Tetramethylpyrazine (TMP) is the main …
Tetramethylpyrazine relieves LPS-induced pancreatic β-cell Min6 injury via regulation of miR-101/MKP-1
PMID: Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):2545-2552. PMID: 31213095 Abstract Title: Tetramethylpyrazine relieves LPS-induced pancreaticβ-cell Min6 injury via regulation of miR-101/MKP-1. Abstract: Tetramethylpyrazine (TMP) is a traditional Chinese medicine with anti-inflammation and immunomodulatory effects. In this context, our purpose was to investigate the associated regulatory mechanisms of TMP against lipopolysaccharide (LPS)-caused pancreaticβ cell Min6 …
Tetramethylpyrazine prevents contrast-induced nephropathy.
PMID: Oxid Med Cell Longev. 2019 ;2019:7096912. Epub 2019 May 16. PMID: 31223426 Abstract Title: Tetramethylpyrazine Prevents Contrast-Induced Nephropathy via Modulating Tubular Cell Mitophagy and Suppressing Mitochondrial Fragmentation, CCL2/CCR2-Mediated Inflammation, and Intestinal Injury. Abstract: Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury (AKI), but detailed pathogenesis and effectual remedy remain elusive. …
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The protective effect of ligustrazine on rats with cerebral ischemia-reperfusion injury via activating PI3K/Akt pathway.
PMID: Hum Exp Toxicol. 2019 Oct ;38(10):1168-1177. Epub 2019 Jun 28. PMID: 31250662 Abstract Title: The protective effect of ligustrazine on rats with cerebral ischemia-reperfusion injury via activating PI3K/Akt pathway. Abstract: The study was to investigate the effects of ligustrazine on rats with cerebral ischemia-reperfusion (I/R) injury and to explore the potential mechanism. Transient focal …
Tetramethylpyrazine enhances the antitumor effect of paclitaxel by inhibiting angiogenesis and inducing apoptosis.
PMID: Front Pharmacol. 2019 ;10:707. Epub 2019 Jun 25. PMID: 31293426 Abstract Title: Tetramethylpyrazine Enhances the Antitumor Effect of Paclitaxel by Inhibiting Angiogenesis and Inducing Apoptosis. Abstract: Recent published findings have demonstrated the effectiveness of combining molecules from traditional Chinese medicine with chemotherapeutic drugs to treat cancer. Combined administration of these agents can overcome drug-mitigating …
The combination of Astragalus membranaceus extract and ligustrazine to improve the inflammation in rats with thrombolytic cerebral ischemia.
n/a PMID: Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869055. PMID: 31409163 Abstract Title: The combination ofextract and ligustrazine to improve the inflammation in rats with thrombolytic cerebral ischemia. Abstract: The purpose of the study was to evaluate the effect ofextract and ligustrazine combination on ameliorating inflammation in cerebral ischemic rats that have undergone thrombolysis.and ligustrazine per …
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