PMID: Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):3465-3477. PMID: 31432702 Abstract Title: Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer. Abstract: Lung cancer is a kind of malignant tumour characterized as uncontrolled cell growth in lung. These malignant cell growth can spread beyond the lung by process …
Author Archives: Taylor Mercado
Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes.
PMID: Life Sci. 2019 Nov 1 ;236:116836. Epub 2019 Sep 4. PMID: 31493479 Abstract Title: Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes. Abstract: AIMS: The present experiment was conceptualised to explore the therapeutic response of tetramethylpyrazine (TMP), a major active constituent of Ligusticum chuanxiong, a Chinese traditional medicinal plant, …
Tetramethylpyrazine alleviates lipopolysaccharide-induced damage in ATDC5 cells via down-regulating MyD88.
PMID: Exp Mol Pathol. 2019 Dec ;111:104317. Epub 2019 Oct 23. PMID: 31655387 Abstract Title: Tetramethylpyrazine alleviates lipopolysaccharide-induced damage in ATDC5 cells via down-regulating MyD88. Abstract: BACKGROUND: Tetramethylpyrazine (TMP) has been reported to play a significant role in the cardiovascular and neuronal diseases. But, the functions of TMP in osteoarthritis (OA) remain unclear. In this …
Tetramethylpyrazine alleviates diabetic nephropathy through the activation of Akt signalling pathway in rats.
PMID: Eur J Pharmacol. 2019 Dec 15 ;865:172763. Epub 2019 Nov 1. PMID: 31682792 Abstract Title: Tetramethylpyrazine alleviates diabetic nephropathy through the activation of Akt signalling pathway in rats. Abstract: In the whole world, the principal cause of end-stage renal disease is diabetic nephropathy (DN), which is one of the most relentless complications of diabetes. …
Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats.
PMID: Microvasc Res. 2019 Nov 1 ;128:103938. Epub 2019 Nov 1. PMID: 31682800 Abstract Title: Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling. Abstract: OBJECTIVE: In the present study, we used a two-kidney-two-clip (2k2c) stroke-prone renovascular hypertension rat model (RHRSP) to investigate the protective effects of ligustrazine (TMP) on …
Tetramethylpyrazine inhibits platelet adhesion and inflammatory response in vascular endothelial cells.
PMID: Inflammation. 2019 Nov 13. Epub 2019 Nov 13. PMID: 31720990 Abstract Title: Tetramethylpyrazine Inhibits Platelet Adhesion and Inflammatory Response in Vascular Endothelial Cells by Inhibiting P38 MAPK and NF-κB Signaling Pathways. Abstract: Damaged vascular endothelial cells after ischemic stroke release inflammatory cytokines and adhesion molecules, which could trigger platelet adhesion to vascular endothelial cells …
Ligustrazine exhibited protective effects against sepsis-associated acute kidney injury.
PMID: Mol Cell Biochem. 2019 Nov 16. Epub 2019 Nov 16. PMID: 31732832 Abstract Title: Ligustrazine suppresses renal NMDAR1 and caspase-3 expressions in a mouse model of sepsis-associated acute kidney injury. Abstract: Sepsis-associated acute kidney injury (AKI) is a life threatening condition with high morbidity and mortality. The pathogenesis of AKI is associated with apoptosis. …
Tetramethylpyrazine reduces epileptogenesis progression.
PMID: ACS Chem Neurosci. 2019 Dec 18 ;10(12):4854-4863. Epub 2019 Dec 6. PMID: 31756074 Abstract Title: Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission. Abstract: Antiepileptic drugs (AEDs) are the primary agents prescribed for clinical management of limbic epilepsy. However, high incidence of pharmacoresistance and a limited armory of drugs …
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Pterostilbene attenuates fructose-induced myocardial fibrosis.
PMID: Oxid Med Cell Longev. 2019 ;2019:1243215. Epub 2019 Dec 4. PMID: 31871537 Abstract Title: Pterostilbene Attenuates Fructose-Induced Myocardial Fibrosis by Inhibiting ROS-Driven Pitx2c/miR-15b Pathway. Abstract: Excessive fructose consumption induces oxidative stress and myocardial fibrosis. Antioxidant compound pterostilbene has cardioprotective effect in experimental animals. This study is aimed at investigating how fructose drove fibrotic responses …
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Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters.
PMID: IBRO Rep. 2019 Dec ;7:90-96. Epub 2019 Oct 22. PMID: 31720488 Abstract Title: Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats. Abstract: This study was undertaken to investigate the Crataegus extract (CE) eff ;ects on diabetes-induced memory deficit in passive avoidance learning (PAL), blood glucose, …
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