Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells.

PMID:  Cancer Cell Int. 2019 ;19:68. Epub 2019 Mar 21. PMID: 30948928 Abstract Title:  Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells. Abstract:  Background: Monoclonal antibodies targeting programmed death-1 receptor (PD-1) and its ligand (PD-L1) have been developed to treat cancers including lung cancer. In this study, we …

Lycopene and resveratrol ameliorate zinc oxide nanoparticles-induced oxidative stress in Nile tilapia, Oreochromis niloticus.

PMID:  Environ Toxicol Pharmacol. 2019 Jul ;69:44-50. Epub 2019 Mar 18. PMID: 30953933 Abstract Title:  Lycopene and resveratrol ameliorate zinc oxide nanoparticles-induced oxidative stress in Nile tilapia, Oreochromis niloticus. Abstract:  Industrial products contained nano-zinc oxide (ZnONP) can gain access to the aquaculture environment causing hazardous effects on the living biota. Therefore, this work was planned …

Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway.

PMID:  Mol Biol Rep. 2019 Jun ;46(3):3387-3397. Epub 2019 Apr 20. PMID: 31006097 Abstract Title:  Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway. Abstract:  Oxidative stress is a key factor of and closely implicated in the pathogenesis of Alzheimer's disease (AD). We herein used tert-butyl hydroperoxide (t-BHP) to …

Lycopene protects myocardial ischemia injury through anti-apoptosis and anti-oxidative stress.

PMID:  Eur Rev Med Pharmacol Sci. 2019 Apr ;23(7):3096-3104. PMID: 31002159 Abstract Title:  Lycopene protects myocardial ischemia injury through anti-apoptosis and anti-oxidative stress. Abstract:  OBJECTIVE: The aim of this research was to explore the protective effect of lycopene (Lyc) on myocardial ischemia injury through anti-apoptosis and anti-oxidative stress.MATERIALS AND METHODS: 75 rats were divided into …

Lycopene ameliorated oxidative stress and inflammation in type 2 diabetes.

PMID:  J Food Sci. 2019 May ;84(5):1194-1200. Epub 2019 Apr 23. PMID: 31012961 Abstract Title:  Lycopene Ameliorated Oxidative Stress and Inflammation in Type 2 Diabetic Rats. Abstract:  We aim to study the antioxidative and anti-inflammatory effects of lycopene on type 2 diabetes mellitus (T2DM) rats, anticipating a complementary strategy for the prevention of long-term complications …

Lycopene restores the effect of ischemic postconditioning on myocardial ischemia‑reperfusion injury in hypercholesterolemic rats.

PMID:  Int J Mol Med. 2019 Jun ;43(6):2451-2461. Epub 2019 Apr 15. PMID: 31017253 Abstract Title:  Lycopene restores the effect of ischemic postconditioning on myocardial ischemia‑reperfusion injury in hypercholesterolemic rats. Abstract:  Ischemic postconditioning (IPoC) has been demonstrated to prevent myocardial ischemia‑reperfusion injury (MIRI), but its cardioprotective effect is abrogated by hypercholesterolemia. The aim of the …

Lycopene supplementation attenuates western diet-induced body weight gain.

PMID:  J Nutr Biochem. 2019 Jul ;69:63-72. Epub 2019 Apr 4. PMID: 31060024 Abstract Title:  Lycopene supplementation attenuates western diet-induced body weight gain through increasing the expressions of thermogenic/mitochondrial functional genes and improving insulin resistance in the adipose tissue of obese mice. Abstract:  This passive overconsumption of western diet has precipitated a steep rise in …

Higher intake and serum levels of most carotenoids were associated with lower odds of having NAFLD.

PMID:  Nutrients. 2019 May 17 ;11(5). Epub 2019 May 17. PMID: 31108934 Abstract Title:  Dietary Carotenoids and Non-Alcoholic Fatty Liver Disease among US Adults, NHANES 2003⁻2014. Abstract:  Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. Oxidative stress is thought to be a major mechanism, and previous epidemiological studies found higher serum levels of antioxidant …

Lycopene protects against renal cortical damage induced by nandrolone decanoate.

PMID:  Ann Anat. 2019 Jul ;224:142-152. Epub 2019 May 17. PMID: 31108192 Abstract Title:  Lycopene protects against renal cortical damage induced by nandrolone decanoate in adult male rats. Abstract:  Nandrolone decanoate is an anabolic androgenic steroid that is abused worldwide by young athletes and bodybuilders to enhance their physical performance. Many clinical reports among those …

The effect of lycopene supplementation on radiation-induced micronuclei in mice reticulocytes in vivo.

PMID:  Radiat Environ Biophys. 2019 08 ;58(3):425-432. Epub 2019 May 23. PMID: 31123854 Abstract Title:  The effect of lycopene supplementation on radiation-induced micronuclei in mice reticulocytes in vivo. Abstract:  Lycopene (LYC) is a natural pigment present in tomatoes and other red fruits and vegetables including red carrots, red peppers, watermelons, pink grapefruits, apricots, pink guavas, …

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