PMID: Cancer Prev Res (Phila). 2019 Jul ;12(7):421-432. Epub 2019 Jun 8. PMID: 31177203 Abstract Title: Lycopene Inhibits Smoke-Induced Chronic Obstructive Pulmonary Disease and Lung Carcinogenesis by Modulating Reverse Cholesterol Transport in Ferrets. Abstract: Chronic obstructive pulmonary disease (COPD) and lung cancer share the same etiologic factor, cigarette smoking. Higher consumption of dietary lycopene has …
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Human papilloma virus DNA binds to the aluminum adjuvant in the HPV vaccine.
PMID: Curr Med Chem. 2014 Mar ;21(7):932-40. PMID: 24083601 Abstract Title: Melting profiles may affect detection of residual HPV L1 gene DNA fragments in Gardasil®. Abstract: Gardasil® is a quadrivalent human papillomavirus (HPV) protein-based vaccine containing genotype-specific L1 capsid proteins of HPV-16, HPV-18, HPV-6 and HPV-11 in the form of virus-like-particles (VLPs) as the active …
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DNA residue purification can increase the residue of short-fragment DNA in vaccines.
PMID: PLoS One. 2016 ;11(4):e0153867. Epub 2016 Apr 15. PMID: 27082865 Abstract Title: Short-Fragment DNA Residue from Vaccine Purification Processes Promotes Immune Response to the New Inactivated EV71 Vaccine by Upregulating TLR9 mRNA. Abstract: To reduce potential oncogenic long genomic DNA in vaccines, nuclease treatment has been applied in the purification processes. However, this action …
Testicular toxicity of gentamicin in adult rats: Ameliorative effect of lycopene.
PMID: Hum Exp Toxicol. 2019 Nov ;38(11):1302-1313. Epub 2019 Jul 18. PMID: 31319718 Abstract Title: Testicular toxicity of gentamicin in adult rats: Ameliorative effect of lycopene. Abstract: The current study was aimed to investigate the ameliorative effect of lycopene against gentamicin-induced testicular toxicity in adult rat testes. Pretreatment with lycopene (4 mg/kg/day) significantly prevented the …
Continue reading “Testicular toxicity of gentamicin in adult rats: Ameliorative effect of lycopene.”
Formaldehyde acts as a co-carcinogen in vitro.
PMID: PLoS One. 2014 ;9(4):e94149. Epub 2014 Apr 10. PMID: 24722772 Abstract Title: Low-dose formaldehyde delays DNA damage recognition and DNA excision repair in human cells. Abstract: OBJECTIVE: Formaldehyde is still widely employed as a universal crosslinking agent, preservative and disinfectant, despite its proven carcinogenicity in occupationally exposed workers. Therefore, it is of paramount importance …
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The carcinogenic effects of long-term low-dose formaldehyde may be related to a disruption of genomic DNA methylation.
PMID: Toxicol Lett. 2011 Sep 10 ;205(3):235-40. Epub 2011 Jul 1. PMID: 21745553 Abstract Title: Effects of long-term low-dose formaldehyde exposure on global genomic hypomethylation in 16HBE cells. Abstract: Formaldehyde (FA), a volatile organic compound, is a ubiquitous air pollutant that is classified as 'Carcinogenic to humans (Group 1)' by IARC (2006). As a well-recognized …
Fluted pumpkin seeds protect against busulfan-induced oxidative stress and testicular injuries.
PMID: Drug Chem Toxicol. 2019 Aug 30:1-11. Epub 2019 Aug 30. PMID: 31469002 Abstract Title: Fluted pumpkin seeds protect against busulfan-induced oxidative stress and testicular injuries in adult mice. Abstract: Fluted pumpkin is traditionally claimed to improve fertility health of male adult subjects. This study evaluated the adjuvant protective potential of fluted pumpkin seeds (FPS) …
Intramuscular polysorbate 80 can induce anaphylaxis.
PMID: J Investig Allergol Clin Immunol. 2016;26(6):394-396. PMID: 27996954 Abstract Title: Anaphylaxis Due to the Excipient Polysorbate 80. Abstract: [n/a] read more
Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells.
PMID: J Physiol Pharmacol. 2019 Aug ;70(4). Epub 2019 Nov 15. PMID: 31741457 Abstract Title: Lycopene induces apoptosis by inhibiting nuclear translocation ofβ-catenin in gastric cancer cells. Abstract: Reactive oxygen species (ROS) promote the development and progression of cancer by their effects on several signaling pathways. Lycopene, a major carotenoid natural product, is known to …
Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress.
PMID: Free Radic Biol Med. 2019 Nov 29. Epub 2019 Nov 29. PMID: 31790829 Abstract Title: Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice. Abstract: Excessive fatty acid uptake-induced oxidative stress causes liver injury and the consecutive recruitment of inflammatory immune cells, thereby promoting the progression of simple steatosis …
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