Reduction of toxic gliadin content of wholegrain bread by the enzyme caricain.

PMID:  Food Chem. 2015 Mar 1 ;170:343-7. Epub 2014 Aug 19. PMID: 25306355 Abstract Title:  Reduction of toxic gliadin content of wholegrain bread by the enzyme caricain. Abstract:  Increasingly the number of individuals being diagnosed with some form of sensitivity to the proteins in wheat grains represents a cause for concern. Currently, the treatment is …

The potential of papain and alcalase enzymes and process optimizations to reduce allergenic gliadins in wheat flour.

n/a PMID:  Food Chem. 2016 Apr 1 ;196:1338-45. Epub 2015 Oct 19. PMID: 26593625 Abstract Title:  The potential of papain and alcalase enzymes and process optimizations to reduce allergenic gliadins in wheat flour. Abstract:  The objectives of this study were to select effective enzymes that catalyze the hydrolysis of allergenic proteins, gliadins, in wheat flour …

Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation.

PMID:  Phytother Res. 2018 Mar ;32(3):480-487. Epub 2017 Dec 15. PMID: 29243291 Abstract Title:  Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation in mice. Abstract:  This study investigated the antiinflammatory properties of betulinic acid (BA) and xylopic acid (XA) extracted from Margaritaria discoidea and Xylopia aethiopica, respectively. …

Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage.

PMID:  Pharmacol Rep. 2018 Jun ;70(3):540-548. Epub 2017 Dec 6. PMID: 29674241 Abstract Title:  Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage in rats: Possible neurotransmitters and neuroinflammatory mechanism. Abstract:  BACKGROUND: The purpose of the study was to explore the therapeutic potential of Betulinic acid (BA) in streptozotocin (STZ) …

Betulinic acid exerts cytotoxic activity against multidrug-resistant tumor cells.

PMID:  Front Pharmacol. 2018 ;9:481. Epub 2018 May 15. PMID: 29867487 Abstract Title:  Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR). Abstract:  Betulinic acid (BetA) is a naturally occurring pentacyclic triterpene isolated from the outer bark of white-barked birch trees and many other medicinal plants. Here, we …

This article details the role of DHA in quantum neurobiology and the evolution of the human brain.

PMID:  Prostaglandins Leukot Essent Fatty Acids. 2013 Jan ;88(1):5-13. Epub 2012 Nov 30. PMID: 23206328 Abstract Title:  A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. Abstract:  Six hundred million years ago, the fossil record displays the sudden appearance of intracellular detail and the 32 phyla. The"Cambrian Explosion"marks …

Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo.

PMID:  J Cell Biochem. 2018 11 ;119(10):8611-8622. Epub 2018 Jun 20. PMID: 29923216 Abstract Title:  Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo. Abstract:  Betulinic acid (BA), a natural product with a broad range of biological properties, is a lupane-type pentacyclic triterpene isolated from various plants. …

Betulinic acid could have a role in Alzheimer’s disease through protecting microcirculation, alleviating inflammation, and up-regulating BDNF expression.

PMID:  Microcirculation. 2018 11 ;25(8):e12503. Epub 2018 Oct 8. PMID: 30178892 Abstract Title:  The protective effect of betulinic acid on microvascular responsivity and protein expression in alzheimer disease induced by cerebral micro-injection of beta-amyloid and streptozotocin. Abstract:  OBJECTIVE: Alzheimer's disease (AD) is mainly caused by accumulation ofβ-amyloid (Aβ) in vessels or parenchyma of the brain. …

Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice.

PMID:  Pharmacol Rep. 2019 Oct ;71(5):929-939. Epub 2019 May 7. PMID: 31450028 Abstract Title:  Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice. Abstract:  BACKGROUND: Betulinic acid (BA) is a plant-derived pentacyclic triterpenoid with a variety of biological activities. The purpose of this study was to assess the potential protective …

Betulinic acid suppresses breast cancer aerobic glycolysis.

PMID:  Biochem Pharmacol. 2019 03 ;161:149-162. Epub 2019 Jan 24. PMID: 30684465 Abstract Title:  Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway. Abstract:  Emerging evidence has suggested that targeting glycolysis may be a promising strategy for cancer treatment. Betulinic acid (BA) is a natural pentacyclic terpene that has been reported to be active …

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