PMID: Metab Brain Dis. 2019 12 ;34(6):1531-1546. Epub 2019 Jul 16. PMID: 31313125 Abstract Title: High fat-low protein diet induces metabolic alterations and cognitive dysfunction in female rats. Abstract: Approximately one-third of the world population is suffering from MetS, and the same is expected to rise in the years to come. Worldwide, most of the …
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High-fructose diet-induced hypertriglyceridemia is associated with enhanced hepatic expression of ACAT2 in rats.
PMID: Physiol Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31647302 Abstract Title: High-fructose diet-induced hypertriglyceridemia is associated with enhanced hepatic expression of ACAT2 in rats. Abstract: High levels of fructose induce hypertriglyceridemia, characterized by excessive levels of triglyceride-rich lipoproteins such as very low-density lipoprotein (VLDL); however, the underlying mechanisms are poorly understood. The …
Kaempferol prevents against Ang II-induced cardiac remodelling through attenuating Ang II-induced inflammation and oxidative stress.
PMID: J Cardiovasc Pharmacol. 2019 Oct ;74(4):326-335. PMID: 31356553 Abstract Title: Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress. Abstract: Heart failure characterized by cardiac remodeling is a global problem. Angiotensin II (Ang II) induces cardiac inflammation and oxidative stress, which also is implicated in the pathophysiology of …
Kaempferol might improve bleomycin-induced fibrosis by reducing oxidative stress, inflammation, and oxidative cellular damage.
PMID: J Dermatol Sci. 2019 Oct ;96(1):8-17. Epub 2019 Aug 16. PMID: 31447184 Abstract Title: Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress. Abstract: BACKGROUND: There is growing evidence that vasculopathy-induced hypoxia and oxidative stress enhance the process of fibrosis in systemic sclerosis (SSc). Kaempferol is a …
Kaempferol reduces hepatic triglyceride accumulation by inhibiting Akt.
PMID: J Food Biochem. 2019 Nov ;43(11):e13034. Epub 2019 Sep 5. PMID: 31489640 Abstract Title: Kaempferol reduces hepatic triglyceride accumulation by inhibiting Akt. Abstract: In this paper, we studied the mechanism of the triglyceride (TG)-lowering effect of kaempferol in vitro and in vivo. Kaempferol showed LXR agonistic activities without inducing TGs or the expression of …
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Kaempferol exhibits anti-pyroptosis activities.
PMID: Immunopharmacol Immunotoxicol. 2019 Oct ;41(5):538-548. Epub 2019 Sep 24. PMID: 31549524 Abstract Title: Kaempferol alleviates LPS-ATP mediated inflammatory injury in splenic lymphocytes via regulation of the pyroptosis pathway in mice. Abstract: The pharmacological application of kaempferol, a natural flavonol present in different plant species, has been demonstrated to have extensive anti-inflammatory, anti-apoptotic, anti-oxidative, and …
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Kaempferol inhibits the progression of silica-induced pulmonary fibrosis.
PMID: DNA Cell Biol. 2019 Sep 27. Epub 2019 Sep 27. PMID: 31560574 Abstract Title: Kaempferol Modulates Autophagy and Alleviates Silica-Induced Pulmonary Fibrosis. Abstract: Silicosis is an occupational disease characterized as inflammatory cells infiltration and severe progressive pulmonary fibrosis. Kaempferol (Kae), a flavonoid exists in many plants and fruits, has been proved to have anti-inflammatory …
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The osteoprotective effects of kaempferol.
PMID: Drug Des Devel Ther. 2019 ;13:3497-3514. Epub 2019 Oct 7. PMID: 31631974 Abstract Title: The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies. Abstract: Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility …
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Kaempferol promotes bone formation in part via the mTOR signaling pathway.
PMID: Mol Med Rep. 2019 Dec ;20(6):5197-5207. Epub 2019 Oct 16. PMID: 31638215 Abstract Title: Kaempferol promotes bone formation in part via the mTOR signaling pathway. Abstract: Previous research indicates that kaempferol (Kae) promotes osteogenesis, but its underlying mechanism of action remains unclear. The present study hypothesized that the osteogenic effects of Kae were mediated …
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Kaempferol could exert anticancer effects in MFE-280 endometrial carcinoma cells selectively.
PMID: J BUON. 2019 Jul-Aug;24(4):1555-1561. PMID: 31646808 Abstract Title: Inhibition of endometrial carcinoma by Kaempferol is interceded through apoptosis induction, G2/M phase cell cycle arrest, suppression of cell invasion and upregulation of m-TOR/PI3K signalling pathway. Abstract: PURPOSE: The main purpose of this study was to investigate the selective anticancer effects of Kaempferol against MFE-280 endometrial …
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