PMID: Adv Exp Med Biol. 2019 ;1182:263-269. PMID: 31777023 Abstract Title: Anti-osteoporosis Effect of Ganoderma (Lingzhi) by Inhibition of Osteoclastogenesis. Abstract: The anti-osteoporosis effect of Ganoderma lucidum (G. lucidum, Lingzhi) is closely associated with inhibition of osteoclastogenesis in the charge of osteoclasts. This article reviewed the anti-osteoporosis effect of Ganoderma and its active components, including …
Author Archives: Taylor Mercado
Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition.
PMID: J Food Biochem. 2020 Jan ;44(1):e13109. Epub 2019 Dec 3. PMID: 31793675 Abstract Title: Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet-fed golden hamsters. Abstract: High-fat diet (HFD) and sucrose intake can lead to hyperlipidemia, hypercholesterolemia, and nonalcoholic fatty liver disease (NAFLD) as well …
Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease.
PMID: Sci Rep. 2019 Dec 13 ;9(1):19059. Epub 2019 Dec 13. PMID: 31836806 Abstract Title: Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease. Abstract: Dengue virus (DENV) infection causes serious health problems in humans for which no drug is currently available. Recently, DENV NS2B-NS3 protease has been proposed as a …
N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury.
PMID: Drug Des Devel Ther. 2018 ;12:4117-4127. Epub 2018 Dec 4. PMID: 30584276 Abstract Title: N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury. Abstract: Background: Increasing evidence demonstrate N-acetylcysteine amide (NACA) provides neuroprotection and attenuated oxidative stress in rats following traumatic brain injury (TBI). The nuclear factor erythroid …
Ganoderma lucidum exerts an anticancer effect on human osteosarcoma cells.
PMID: Integr Cancer Ther. 2019 Jan-Dec;18:1534735419890917. PMID: 31855073 Abstract Title: Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/β-Catenin Signaling Pathway. Abstract: Current treatment of osteosarcoma is limited in part by side effects and low tolerability, problems generally avoided with traditional Chinese medicine., a traditional Chinese medicine with antitumor effects, offers a …
Continue reading “Ganoderma lucidum exerts an anticancer effect on human osteosarcoma cells.”
N-acetylcysteine protects hepatocytes from hypoxia-related cell injury
PMID: Clin Exp Hepatol. 2018 Dec ;4(4):260-266. Epub 2018 Dec 3. PMID: 30603674 Abstract Title: N-acetylcysteine protects hepatocytes from hypoxia-related cell injury. Abstract: Aim of the study: Hepatocyte transplantation has been discussed as an alternative to liver transplantation in selected cases of acute and chronic liver failure and metabolic diseases. Immediately after infusion of hepatocytes, …
Continue reading “N-acetylcysteine protects hepatocytes from hypoxia-related cell injury”
N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling.
PMID: J Exp Clin Cancer Res. 2019 Jan 3 ;38(1):2. Epub 2019 Jan 3. PMID: 30606241 Abstract Title: N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling. Abstract: BACKGROUND: Glioblastomas multiforme (GBM) is the most devastating primary intracranial malignancy lacking effective clinical treatments. Notch2 has been established to be a prognostic marker and …
Protective action of N-acetylcysteine on sperm quality in cyclophosphamide-induced testicular toxicity.
PMID: JBRA Assist Reprod. 2019 Apr 30 ;23(2):83-90. Epub 2019 Apr 30. PMID: 30633472 Abstract Title: Protective action of N-acetylcysteine on sperm quality in cyclophosphamide-induced testicular toxicity in male Wistar rats. Abstract: BACKGROUND: Reductions in sperm quality due to free radical formation during cancer chemotherapy are well documented, hence the need for an adjunct antioxidant …
N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation.
PMID: Reprod Toxicol. 2019 03 ;84:98-107. Epub 2019 Jan 8. PMID: 30633982 Abstract Title: N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation. Abstract: We previously investigated excessive fluoride exposure elicited intracellular endoplasmic reticulum (ER) stress and led to Sertoli cells dysfunction in vitro. However, the mechanisms underlying fluoride-mediated male reproductive …
NAC is marginally effective in prevention and treatment of experimental gingivitis.
PMID: Clin Oral Investig. 2019 Oct ;23(10):3833-3842. Epub 2019 Jan 23. PMID: 30673864 Abstract Title: N-acetyl cysteine versus chlorhexidine mouthwashes in prevention and treatment of experimental gingivitis: a randomized, triple-blind, placebo-controlled clinical trial. Abstract: OBJECTIVES: To compare the efficacy of N-acetyl cysteine (NAC) mouthwash with chlorhexidine (CHX) in prevention and treatment of experimental gingivitis MATERIALS …
Health Time 