Author Archives: Taylor Mercado

PMID:  Shock. 2019 Dec ;52(6):622-630. PMID: 30676497 Abstract Title:  N-Acetylcysteine Ameliorates Gentamicin-Induced Nephrotoxicity by Enhancing Autophagy and Reducing Oxidative Damage in Miniature Pigs. Abstract:  The clinical use of gentamicin over prolonged periods is limited because of dose and time-dependent nephrotoxicity, in which intracellular oxidative stress and heightened inflammation have been implicated. Macroautophagy/autophagy is an essential …

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PMID:  Reprod Biol Endocrinol. 2019 Feb 16 ;17(1):24. Epub 2019 Feb 16. PMID: 30771790 Abstract Title:  Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men. Abstract:  BACKGROUND: Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can …

Continue reading “NAC oral supplementation may improve sperm parameters and oxidative/antioxidant status in infertile males.”

PMID:  Wounds. 2019 04 ;31(4):91-96. Epub 2019 Feb 14. PMID: 30802208 Abstract Title:  Topical and Systemic Effects of N-acetyl Cysteine on Wound Healing in a Diabetic Rat Model. Abstract:  OBJECTIVE: This study evaluates the effects of topical and systemic N-acetyl cysteine (NAC) treatment on wound healing in a diabetic rat model.MATERIALS AND METHODS: A total …

Continue reading “Both topical and systemic administration of NAC improved wound healing in a diabetic rat model.”

PMID:  J Antimicrob Chemother. 2019 Aug 1 ;74(8):2188-2196. PMID: 31102529 Abstract Title:  N-acetylcysteine blocks SOS induction and mutagenesis produced by fluoroquinolones in Escherichia coli. Abstract:  BACKGROUND: Fluoroquinolones such as ciprofloxacin induce the mutagenic SOS response and increase the levels of intracellular reactive oxygen species (ROS). Both the SOS response and ROS increase bacterial mutagenesis, fuelling …

Continue reading “N-acetylcysteine blocks SOS induction and mutagenesis produced by fluoroquinolones in Escherichia coli.”

PMID:  Clin Pharmacol Ther. 2019 Oct ;106(4):884-890. Epub 2019 Jul 17. PMID: 31206613 Abstract Title:  N-Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease. Abstract:  This study assessed the biological and clinical effects in patients with Parkinson's disease (PD) of N-acetyl-cysteine (NAC), the prodrug to l-cysteine, a precursor to the natural biological antioxidant glutathione. …

Continue reading “N-acetylcysteine is associated with dopaminergic improvement in Parkinson’s disease.”

PMID:  J Food Biochem. 2019 Aug ;43(8):e12950. Epub 2019 Jun 18. PMID: 31368551 Abstract Title:  Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury in male rats based on serum biochemical parameters, oxidative biomarkers, and histopathological study. Abstract:  Diclofenac (DIC) can cause nephrotoxicity in humans. In this study, we evaluated the protective effects of N-acetyl …

Continue reading “Ameliorative effects of N-acetyl cysteine on diclofenac-induced renal injury.”

PMID:  Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Aug 30 ;41(4):529-535. PMID: 31484617 Abstract Title:  [Effect of N-acetylcysteine on Cognitive Function and Nuclear Factor Erythroid 2 Related Factor 2/Heme Oxygenase-1 Pathway in Mouse Models of Postoperative Cognitive Dysfunction]. Abstract:  To investigate the effect of N-acetylcysteine(NAC)on cognitive function and nuclear factor erythroid 2 related …

Continue reading “Beneficial effects of N-acetylcysteine on cognitive function and in a mouse models of postoperative cognitive dysfunction.”

PMID:  Arch Physiol Biochem. 2019 Oct ;125(4):332-343. Epub 2018 Apr 17. PMID: 29663826 Abstract Title:  Antioxidant and hepato-preventive effect ofextract against carbon tetrachloride-induced hepatotoxicity in rats and characterisation of its bioactive compounds by HPLC-MS. Abstract:  The objective of this study is to explore the preventive effects of ethyl acetate fraction fromleaf extract (EACA), associated with …

Continue reading “Antioxidant and hepato-preventive effect of Citrus aurantium extract against carbon tetrachloride-induced hepatotoxicity.”

PMID:  Molecules. 2019 Nov 13 ;24(22). Epub 2019 Nov 13. PMID: 31766122 Abstract Title:  The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan ofBY4742. Abstract:  The anti-aging activity of many plant flavonoids, as well as their mechanisms of action, have been explored in the current literature. However, …

Continue reading “The anti-aging potential of neohesperidin and its synergistic effects with other citrus flavonoids.”

PMID:  Pharmacol Res. 2019 10 ;148:104460. Epub 2019 Sep 24. PMID: 31560944 Abstract Title:  Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota. Abstract:  Neohesperidin (NHP), derived from citrus fruits, has attracted considerable interest due to its preventative and therapeutic effects on numerous diseases. However, little progress has been made in determining the exact function …

Continue reading “Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota.”