PMID: Eur J Pharmacol. 2019 Dec 1 ;864:172712. Epub 2019 Oct 2. PMID: 31586469 Abstract Title: Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice. Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal growing problem, with limited therapeutic options. Transforming growth factor beta 1 (TGF-β1) plays a critical role in many pathological processes …
Author Archives: Taylor Mercado
Neohesperidin suppresses IgE-mediated anaphylactic reactions.
PMID: Phytother Res. 2019 Aug ;33(8):2034-2043. Epub 2019 Jun 14. PMID: 31197891 Abstract Title: Neohesperidin suppresses IgE-mediated anaphylactic reactions and mast cell activation via Lyn-PLC-Capathway. Abstract: Mast cells play an essential role in IgE-FcεR1-mediated allergic diseases. Citrus aurantium is a prolific source of flavonoids with various biological activities, including anti-inflammatory, antioxidant, and anti-tumor efficacies. Neohesperidin …
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Polyphenols from blossoms of Citrus aurantium show significant anti-complement and anti-inflammatory effects.
PMID: J Agric Food Chem. 2017 Oct 18 ;65(41):9061-9068. Epub 2017 Oct 9. PMID: 28942652 Abstract Title: Polyphenols from Blossoms of Citrus aurantium L. var. amara Engl. Show Significant Anti-Complement and Anti-Inflammatory Effects. Abstract: Citrus aurantium L. var. amara Engl. (CAVA) was traditionally used as a digestant or expectorant in China. Crude polyphenols (CAVAP-W) extracted …
N-acetyl cysteine protects against chlorine-induced tissue damage.
PMID: Toxicol Lett. 2020 Jan 18. Epub 2020 Jan 18. PMID: 31962155 Abstract Title: N-acetyl cysteine protects against chlorine-induced tissue damage in an ex vivo model. Abstract: High-level concentrations of chlorine (Cl) can cause life-threatening lung injuries and the objective in this study was to understand the pathogenesis of short-term sequelae of Cl-induced lung injury …
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N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes.
PMID: Neurochem Int. 2020 Jan ;132:104605. Epub 2019 Nov 18. PMID: 31751620 Abstract Title: N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes. Abstract: Depression is highly comorbid with anxiety disorders and associated with profound cognitive impairment. Moreover, cognitive deficits associated with hippocampal dysfunction are central in …
Polysaccharide of Hericium erinaceus attenuates colitis.
PMID: J Nutr Biochem. 2018 07 ;57:67-76. Epub 2018 Mar 16. PMID: 29677563 Abstract Title: Polysaccharide of Hericium erinaceus attenuates colitis in C57BL/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota. Abstract: Inflammatory bowel disease (IBD) is a disease caused by a dysregulated immune with unknown …
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Regenerative activity of Hericium erinaceus on axonal injury model using in vitro laser microdissection technique.
PMID: Neurol Res. 2019 Mar ;41(3):265-274. Epub 2018 Dec 20. PMID: 30570422 Abstract Title: Regenerative activity of Hericium erinaceus on axonal injury model using in vitro laser microdissection technique. Abstract: OBJECTIVE: Peripheral nerve injury (PNI) is an important global health problem. Nerve Growth Factor (NGF) plays crucial role in the survival, growth, and maintenance of …
Improvement of cognitive functions by oral intake of Hericium erinaceus
PMID: Biomed Res. 2019 ;40(4):125-131. PMID: 31413233 Abstract Title: Improvement of cognitive functions by oral intake of Hericium erinaceus. Abstract: Hericium erinaceus has been recognized as medical mushroom since ancient time, but its scientific evidence for human health has been still uncertain. In this study, we tested a randomized, double-blind, placebo-controlled parallel-group comparative study to …
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A novel Hericium erinaceus polysaccharide prevents H2O2-induced oxidative damage in GES-1 cells.
PMID: Int J Biol Macromol. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31759012 Abstract Title: A novel Hericium erinaceus polysaccharide: Structural characterization and prevention of HO-induced oxidative damage in GES-1 cells. Abstract: In this paper, the structural characteristics and bioactivity of a novel polysaccharide from H. erinaceus (HEP) were investigated, wherein, physico-chemical characterization demonstrated …
Hericium erinaceus polysaccharide could be explored as potential antioxidant agents for deoxynivalenol-induced intestinal mucosa injury.
PMID: Int J Biol Macromol. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31759000 Abstract Title: Characterization of polysaccharides isolated from Hericium erinaceus and their protective effects on the DON-induced oxidative stress. Abstract: In this study, the structure characteristic of the Hericium erinaceus polysaccharide (HEP) was investigated using Fourier transformed infrared spectrometry (FT-IR), gas chromatography-mass …
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