PMID: Chronobiol Int. 2019 Dec 2:1-12. Epub 2019 Dec 2. PMID: 31790604 Abstract Title: Melatonin ingestion after exhaustive late-evening exercise attenuate muscle damage, oxidative stress, and inflammation during intense short term effort in the following day in teenage athletes. Abstract: The present study aimed to investigate whether nocturnal melatonin (MEL) ingestion has beneficial effects against …
Category Archives: Uncategorized
The role of melatonin in colorectal cancer.
PMID: J Gastrointest Cancer. 2019 Dec 2. Epub 2019 Dec 2. PMID: 31792737 Abstract Title: The Role of Melatonin in Colorectal Cancer. Abstract: The prevalence and mortality rate of colorectal cancer have been dramatically rising globally. Currently, colorectal cancer is emerging as the fourth leading cause of death and the third most common malignancy worldwide. …
Continue reading “The role of melatonin in colorectal cancer.”
Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype.
PMID: CNS Neurosci Ther. 2019 Dec ;25(12):1353-1362. PMID: 31793209 Abstract Title: Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway. Abstract: AIMS: Microglia and infiltrated macrophages play important roles in inflammatory processes after ischemic stroke. Modulating microglia/macrophage polarization from pro-inflammatory phenotype to anti-inflammatory state has been suggested as a …
Melatonin: an anti-tumor agent for osteosarcoma
PMID: Cancer Cell Int. 2019 ;19:319. Epub 2019 Nov 29. PMID: 31798348 Abstract Title: Melatonin: an anti-tumor agent for osteosarcoma. Abstract: Osteosarcoma is the most common bone tumors which consisted of malignant mesenchymal cells generating osteoid and immature bone. It has been showed that osteosarcoma is common in children and adolescents and shows high mortality …
Continue reading “Melatonin: an anti-tumor agent for osteosarcoma”
The effects of melatonin on signaling pathways and molecules involved in glioma.
PMID: Fundam Clin Pharmacol. 2019 Dec 6. Epub 2019 Dec 6. PMID: 31808968 Abstract Title: The effects of melatonin on signaling pathways and molecules involved in glioma. Abstract: Glioblastoma is one of the most common brain tumors with high invasion and malignancy. Despite extensive research in this area and the use of new and advanced …
Continue reading “The effects of melatonin on signaling pathways and molecules involved in glioma.”
Melatonin protects bone against cadmium-induced toxicity via activation of Wnt/β-catenin signaling pathway.
PMID: Toxicol Mech Methods. 2019 Dec 11:1-9. Epub 2019 Dec 11. PMID: 31809235 Abstract Title: Melatonin protects bone against cadmium-induced toxicity via activation of Wnt/β-catenin signaling pathway. Abstract: Among heavy metals, cadmium (Cd) is one of the most toxic for health due to it accumulation in several tissues including bone. Since melatonin (MLT) favors new …
Melatonin protects blood-brain barrier integrity and permeability.
PMID: Aging (Albany NY). 2019 Dec 7 ;11. Epub 2019 Dec 7. PMID: 31811815 Abstract Title: Melatonin protects blood-brain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-κB pathway. Abstract: The pathophysiological mechanism of white matter hyperintensities of cerebral small vessel disease (CSVD) includes an impaired blood-brain barrier (BBB) with increased permeability. Neuroinflammation …
Continue reading “Melatonin protects blood-brain barrier integrity and permeability.”
Melatonin ameliorated sodium fluoride-induced testicular metabolic stress.
PMID: Biol Trace Elem Res. 2019 Dec 11. Epub 2019 Dec 11. PMID: 31828722 Abstract Title: Fluoride Compromises Testicular Redox Sensor, Gap Junction Protein, and Metabolic Status: Amelioration by Melatonin. Abstract: The excess fluoride intake has been shown to adversely affect male reproductive health. The aim of the present study was to investigate the key …
Continue reading “Melatonin ameliorated sodium fluoride-induced testicular metabolic stress.”
Melatonin may be used as a probiotic agent to reverse sleep deprivation-induced small intestinal mucosa injury.
PMID: Int Immunopharmacol. 2019 Dec 10 ;78:106041. Epub 2019 Dec 10. PMID: 31835081 Abstract Title: Melatonin alleviates oxidative stress in sleep deprived mice: Involvement of small intestinal mucosa injury. Abstract: BACKGROUND: Previous research demonstrated that sleep deprivation (SD) resulted in intestinal homeostasis disorder in colon. The present study was further performed to clarify the role …
Prevention of dental caries by grape seed extract supplementation.
PMID: Nutr Health. 2019 Nov 24:260106019887890. Epub 2019 Nov 24. PMID: 31760860 Abstract Title: Prevention of dental caries by grape seed extract supplementation: A systematic review. Abstract: BACKGROUND: Dental caries are the most prominent chronic disease of children and adults worldwide, and facilitating evidence-based, preventative care for their prevention is critical. Caries are traditionally and …
Continue reading “Prevention of dental caries by grape seed extract supplementation.”
Health Time 