PMID: Phytother Res. 2019 Nov 22. Epub 2019 Nov 22. PMID: 31755173 Abstract Title: Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain. Abstract: Osteoarthritis (OA) pain has been proposed to be a mixed pain state, because in some patients, central nervous system factors are superimposed upon the more traditional peripheral factors. …
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Vitamin C inhibits lipid deposition through GSK-3β/mTOR signaling in the liver of zebrafish.
PMID: Fish Physiol Biochem. 2019 Nov 28. Epub 2019 Nov 28. PMID: 31782040 Abstract Title: Vitamin C inhibits lipid deposition through GSK-3β/mTOR signaling in the liver of zebrafish. Abstract: In this study, the mechanism that VC inhibits lipid deposition through GSK-3β/mTOR signaling was investigated in the liver of Danio rerio. The results indicated that 0.5- …
Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain.
PMID: Neurosci Lett. 2019 Nov 30:134656. Epub 2019 Nov 30. PMID: 31794791 Abstract Title: Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats. Abstract: Tetrahydrobiopterin (BH4) is a cofactor for tyrosine hydroxylase and tryptophan hydroxylase, which are essential enzymes for the biosynthesis of dopamine, norepinephrine, and …
Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.
PMID: Naunyn Schmiedebergs Arch Pharmacol. 2006 Oct ;374(1):11-20. Epub 2006 Sep 9. PMID: 16964520 Abstract Title: Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. Abstract: Betulinic acid (BA) is a pentacyclic triterpene found in many plant species, among others in the bark of white birch …
Betulinic acid induces apoptosis in human neuroblastoma cell lines.
PMID: Eur J Cancer. 1997 Oct ;33(12):2007-10. PMID: 9516843 Abstract Title: Betulinic acid induces apoptosis in human neuroblastoma cell lines. Abstract: Neuroblastoma has long been recognized to show spontaneous regression during fetal development and in the majority of stage 4s infants read more
Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.
PMID: Br J Cancer. 2010 Jun 29 ;103(1):43-51. Epub 2010 Jun 1. PMID: 20517313 Abstract Title: Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma. Abstract: BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood with the ability to resist apoptosis by the activation of survival promoting and anti-apoptotic proteins.METHODS: Efficacy of …
Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.
PMID: Br J Cancer. 2004 Apr 19 ;90(8):1672-8. PMID: 15083202 Abstract Title: Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice. Abstract: We examined the antitumour effect of a combination of betulinic acid (BA) and vincristine (VCR) on murine melanoma B16F10 cells in vitro and …
Betulinic acid-induced apoptosis in leukemia cells.
PMID: Leukemia. 2004 Aug ;18(8):1406-12. PMID: 15201849 Abstract Title: Betulinic acid-induced apoptosis in leukemia cells. Abstract: Betulinic acid (BA), a natural component isolated from Birch trees, effectively induces apoptosis in neuroectodermal and epithelial tumor cells and exerts little toxicity in animal trials. Here, we show that BA-induced marked apoptosis in 65% of primary pediatric acute …
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Pomegranate’s Performance-Boosting Potential Confirmed
Pomegranate extract provides a natural way to boost athletic performance, increasing the time to exhaustion by more than 1.5 minutes among a group of amateur cyclists
Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia.
PMID: Int J Hyperthermia. 2002 Mar-Apr;18(2):153-64. PMID: 11911485 Abstract Title: Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia. Abstract: Betulinic acid is a known inducer of apoptosis in human melanoma that is most effective under conditions of low pH. It was hypothesized that betulinic acid, in combination with acute acidification and/or …
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