PMID: PLoS One. 2013 ;8(2):e56234. Epub 2013 Feb 12. PMID: 23424652 Abstract Title: Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity. Abstract: Inhibition of the ubiquitin-proteasome system (UPS) of protein degradation is a valid anti-cancer strategy and has led to the approval of bortezomib for …
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Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro.
PMID: Int Immunopharmacol. 2013 Oct ;17(2):184-90. Epub 2013 Jun 28. PMID: 23816536 Abstract Title: Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro. Abstract: Ethanol consumption leads to many kinds of liver injury and suppresses innate immunity, but the molecular mechanisms have not been fully delineated. …
Overweight? Cumin Spice Works Better Than Obesity Drugs
Cumin, a warm, peppery seed found in spice cabinets around the globe, helped overweight individuals lose as much weight as those taking weight loss medication, with added benefits to insulin levels
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CrossFit Settles Lawsuit with HHS After Agency Releases Email Showing Continued Efforts to Conceal Donations
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Betulinic acid alleviates non-alcoholic fatty liver.
PMID: Biochem Pharmacol. 2013 May 1 ;85(9):1330-40. Epub 2013 Feb 19. PMID: 23435355 Abstract Title: Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway. Abstract: Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. The discovery of food components that can ameliorate …
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Betulinic acid has apoptotic activity against head and neck squamous cell carcinoma.
PMID: Head Neck. 2003 Sep ;25(9):732-40. PMID: 12953308 Abstract Title: Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells. Abstract: BACKGROUND: A new compound, betulinic acid, has been found to be cytotoxic against a variety of tumor cells originating from the neural crest. Its efficacy against head and neck squamous cellular …
Beneficial effect of betulinic acid on hyperglycemia via suppression of hepatic glucose production.
PMID: J Agric Food Chem. 2014 Jan 15 ;62(2):434-42. Epub 2013 Dec 30. PMID: 24354358 Abstract Title: Beneficial effect of betulinic acid on hyperglycemia via suppression of hepatic glucose production. Abstract: The inhibitory effect of betulinic acid (BA) on hepatic glucose production was examined in HepG2 cells and high fat diet (HFD)-fed ICR mice. BA …
Betulinic acid protects against cerebral ischemia-reperfusion injury.
PMID: Nitric Oxide. 2011 Apr 30 ;24(3):132-8. Epub 2011 Feb 1. PMID: 21292018 Abstract Title: Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress. Abstract: Increased production of reactive oxygen and nitrogen species following cerebral ischemia-reperfusion is a major cause for neuronal injury. In hypercholesterolemic apolipoprotein E knockout (ApoE-KO) …
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