PMID: Toxicol Sci. 2006 Sep ;93(1):75-81. Epub 2006 Jun 21. PMID: 16790488 Abstract Title: Estrogen-like response to p-nonylphenol in human first trimester placenta and BeWo choriocarcinoma cells. Abstract: p-Nonylphenol (p-NP) is a metabolite of alkylphenol ethoxylates used as surfactants in the manufacturing industry. Although it is reported to have estrogenic activity and to be transferred …
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Prenatal exposure to air pollution has been implicated in autism spectrum disorder risk and there is a need for further exploration into prenatal nutrients, metabolic conditions, and exposure to endocrine-disrupting chemicals.
PMID: Annu Rev Public Health. 2017 Mar 20 ;38:81-102. Epub 2016 Dec 21. PMID: 28068486 Abstract Title: The Changing Epidemiology of Autism Spectrum Disorders. Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with lifelong impacts. Genetic and environmental factors contribute to ASD etiology, which remains incompletely understood. Research on ASD epidemiology has made …
Prenatal exposures to endocrine disruptors, heavy metals, and other environmental contaminants can result in fetal epigenomic changes.
PMID: Epigenomics. 2017 03 ;9(3):333-350. Epub 2017 Feb 17. PMID: 28234024 Abstract Title: Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome. Abstract: Exposure to environmental contaminants during pregnancy has been linked to adverse outcomes at birth and later in life. The link between prenatal exposures and latent health outcomes …
Epigenetic modification can be inherited by multiple generations in C. elegans.
PMID: Science. 2017 04 21 ;356(6335):320-323. PMID: 28428426 Abstract Title: Transgenerational transmission of environmental information in. Abstract: The environment experienced by an animal can sometimes influence gene expression for one or a few subsequent generations. Here, we report the observation that a temperature-induced change in expression from aheterochromatic gene array can endure for at least …
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The epigenome is most susceptible to dysregulation during embryogenesis, highlighting the importance of environmental factors during pregnancy.
PMID: Reprod Toxicol. 2011 Apr ;31(3):363-73. Epub 2011 Jan 20. PMID: 21256208 Abstract Title: Prenatal environmental exposures, epigenetics, and disease. Abstract: This review summarizes recent evidence that prenatal exposure to diverse environmental chemicals dysregulates the fetal epigenome, with potential consequences for subsequent developmental disorders and disease manifesting in childhood, over the lifecourse, or even transgenerationally. …
This study finds evidence to suggest a mutation in the PTCHD1 gene as a contributor to autism risk.
PMID: Sci Transl Med. 2010 Sep 15 ;2(49):49ra68. PMID: 20844286 Abstract Title: Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. Abstract: Autism is a common neurodevelopmental disorder with a complex mode of inheritance. It is one of the most highly heritable of the complex disorders, although the underlying genetic …
This review details the available evidence on the etiology of autism.
PMID: Cell Mol Neurobiol. 2010 Mar ;30(2):161-71. Epub 2009 Sep 23. PMID: 19774457 Abstract Title: Understanding and determining the etiology of autism. Abstract: Worldwide, the rate of autism has been steadily rising. There are several environmental factors in concert with genetic susceptibilities that are contributing to this rise. Impaired methylation and mutations of mecp2 have …
Continue reading “This review details the available evidence on the etiology of autism.”
This review discusses the epigenetic modifications in autism.
PMID: Adv Exp Med Biol. 2017 ;978:63-90. PMID: 28523541 Abstract Title: Epigenetics of Autism Spectrum Disorder. Abstract: Autism spectrum disorder (ASD), one of the most common childhood neurodevelopmental disorders (NDDs), is diagnosed in 1 of every 68 children. ASD is incredibly heterogeneous both clinically and aetiologically. The etiopathogenesis of ASD is known to be complex, …
Continue reading “This review discusses the epigenetic modifications in autism.”
Sudden and unexpected deaths have been reported after the administration of hexavalent vaccines.
PMID: Eur J Pediatr. 2005 Feb ;164(2):61-9. Epub 2004 Dec 16. PMID: 15602672 Abstract Title: Sudden and unexpected deaths after the administration of hexavalent vaccines (diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, Haemophilius influenzae type b): is there a signal? Abstract: UNLABELLED: Deaths in temporal association with vaccination of hexavalent vaccines have been recently reported. The …
Although only 1% of vaccine adverse events are reported to VAERS, the system received 29,747 reports after Hib vaccines. 5179 were serious and 896 were reported deaths, with 51% of the deaths being attributed to Sudden Infant Death Syndrome.
PMID: J Pediatr. 2015 Apr ;166(4):992-7. Epub 2015 Jan 15. PMID: 25598306 Abstract Title: Adverse events following Haemophilus influenzae type b vaccines in the Vaccine Adverse Event Reporting System, 1990-2013. Abstract: OBJECTIVE: To characterize adverse events (AEs) after Haemophilus influenzae type b (Hib) vaccines reported to the US Vaccine Adverse Event Reporting System (VAERS), a …
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