PMID: Annu Rev Physiol. 2019 Nov 18. Epub 2019 Nov 18. PMID: 31738670 Abstract Title: Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior. Abstract: Endocrine disrupting chemicals are common in our environment and act on hormone systems and signaling pathways to alter physiological homeostasis. Gestational exposure can disrupt developmental …
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In vivo analysis of Bisphenol A induced dose-dependent adverse effects in cauda epididymis of mice.
PMID: Interdiscip Toxicol. 2018 Oct ;11(3):209-216. Epub 2019 Oct 18. PMID: 31736635 Abstract Title: analysis of Bisphenol A induced dose-dependent adverse effects in cauda epididymis of mice. Abstract: Bisphenol A is widely used as a material for the production of epoxy resins and polycarbonate plastics. It contaminates various food stuffs by getting leached out from …
A review on sources and health impacts of bisphenol A.
PMID: Rev Environ Health. 2019 Nov 19. Epub 2019 Nov 19. PMID: 31743105 Abstract Title: A review on sources and health impacts of bisphenol A. Abstract: Bisphenol-A (BPA) is a synthetic chemical used in the manufacturing of polycarbonates and epoxy resins. This paper is a review of studies reporting the occurrences and concentrations of BPA …
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Triclosan stimulates human vascular endothelial cell injury.
PMID: Chemosphere. 2019 Oct 8 ;241:125077. Epub 2019 Oct 8. PMID: 31614311 Abstract Title: Triclosan stimulates human vascular endothelial cell injury via repression of the PI3K/Akt/mTOR axis. Abstract: Triclosan (TCS) has potentially toxic effects on humans and animals. However, the possible roles and mechanisms of TCS in endothelial cells (ECs) are still unknown. Abnormal damage …
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Lipid metabolism disorders contribute to hepatotoxicity of triclosan in mice.
PMID: J Hazard Mater. 2019 Sep 24 ;384:121310. Epub 2019 Sep 24. PMID: 31586915 Abstract Title: Lipid metabolism disorders contribute to hepatotoxicity of triclosan in mice. Abstract: Previous in vivo exposure studies focused mainly on nuclear receptors involved in hepatotoxicity of triclosan (TCS). As liver plays a vital role in metabolic processes, dysregulations in lipid …
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L-carnitine supplementation at doses above 2 gram a day has favourable effects on patients’ lipid profiles.
PMID: Nutr Metab Cardiovasc Dis. 2019 Nov ;29(11):1151-1167. Epub 2019 Jul 24. PMID: 31561944 Abstract Title: Efficacy of l-carnitine supplementation for management of blood lipids: A systematic review and dose-response meta-analysis of randomized controlled trials. Abstract: BACKGROUND AND AIM: l-carnitine has an important role in fatty acid metabolism and could therefore act as an adjuvant …
L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet.
PMID: Dig Liver Dis. 2019 Oct 10. Epub 2019 Oct 10. PMID: 31607566 Abstract Title: L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet. Abstract: Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disorder. NAFLD, associated lipotoxicity, fibrosis, oxidative stress, and altered …
This meta-analysis has shown that L-carnitine supplementation significantly reduces FPG, insulin, HOMA-IR, and HbA1c levels.
PMID: EXCLI J. 2019 ;18:631-643. Epub 2019 Aug 19. PMID: 31611746 Abstract Title: The effects of L-carnitine supplementation on glycemic control: a systematic review and meta-analysis of randomized controlled trials. Abstract: The findings of trials investigating the effect of L-carnitine administration on glycemic control are controversial. This meta-analysis of randomized controlled trials (RCTs) was performed …
Protective effects of olmesartan and L-carnitine on doxorubicin-induced cardiotoxicity.
PMID: Can J Physiol Pharmacol. 2019 Oct 30. Epub 2019 Oct 30. PMID: 31665614 Abstract Title: Protective Effects of Olmesartan and L-carnitine on Doxorubicin-Induced Cardiotoxicity in Rats. Abstract: Doxorubicin (DOX), anthracycline antibiotic, is an important antineoplastic agent due to its high antitumor efficacy in hematological, as well as in solid malignancies. The present study aimed …
Carnitine supplementation improves acetylcarnitine formation and rescues metabolic flexibility in impaired glucose tolerant-subjects.
PMID: EBioMedicine. 2019 Nov ;49:318-330. Epub 2019 Oct 31. PMID: 31676389 Abstract Title: Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. Abstract: BACKGROUND: Type 2 diabetes patients and individuals at risk of developing diabetes are characterized by metabolic inflexibility and disturbed glucose homeostasis. …
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