PMID: Trends Immunol. 2010 Mar ;31(3):103-9. Epub 2010 Feb 10. PMID: 20153253 Abstract Title: The immunobiology of aluminium adjuvants: how do they really work? Abstract: Aluminium adjuvants potentiate the immune response, thereby ensuring the potency and efficacy of typically sparingly available antigen. Their concomitant critical importance in mass vaccination programmes may have prompted recent intense …
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Artichoke leaf extract has liver protective effects and causes downregulation of oxidative stress in acute diazinon-induced liver injury.
PMID: J Basic Clin Physiol Pharmacol. 2019 Aug 30 ;30(5). Epub 2019 Aug 30. PMID: 31469651 Abstract Title: Modulatory effects of artichoke (Cynara scolymus L.) leaf extract against oxidative stress and hepatic TNF-α gene expression in acute diazinon-induced liver injury in rats. Abstract: Background Diazinon (DZN) causes serious liver damage in both humans and animals. …
Consumption of C. scolymus powder as a rich source of phenolic and antioxidant compounds could potentially improve BMI and SBP in hypertensive patients.
PMID: Complement Med Res. 2019 Sep 4:1-6. Epub 2019 Sep 4. PMID: 31484191 Abstract Title: The Effect of Cynara scolymus on Blood Pressure and BMI in Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial. Abstract: BACKGROUND: Recent studies have suggested that artichoke (Cynara scolymus L.) may reduce certain biochemical blood factors but the efficacy of …
Aluminum is predominantly identified in macrophages after administration to normal mice.
PMID: Pharmacol Toxicol. 1996 Mar ;78(3):123-8. PMID: 8882343 Abstract Title: Effect of aluminium hydroxide administration on normal mice: tissue distribution and ultrastructural localization of aluminium in liver. Abstract: In order to assess the risk of parenteral aluminium (Al) exposure, we evaluated the effects of intraperitoneal administration of aluminium hydroxide, a compound widely used in medicine. …
Effect of Artichoke on cardiac markers, lipid profile and antioxidants levels in tissue of HFD-induced obesity.
PMID: Arch Physiol Biochem. 2019 Sep 28:1-11. Epub 2019 Sep 28. PMID: 31564131 Abstract Title: Effect of Artichoke () on cardiac markers, lipid profile and antioxidants levels in tissue of HFD-induced obesity. Abstract: Obesity plays a pivotal role in the insulin resistance disease, which is related to hypertension, hyperlipidemia, type 2 diabetes mellitus, and an …
Aluminum ingestion is absorbed and may accumulate in different organs in both adults and infants.
PMID: Rev Environ Health. 1991 Oct-Dec;9(4):191-205. PMID: 1842454 Abstract Title: Aluminum ingestion–is it related to dementia? Abstract: Elevated levels of aluminum in brain tissue have been found in demented patients with Alzheimer's disease, with ALS-PD complex of Guam and with dialysis encephalopathy. A possible etiological relationship between enhanced aluminum exposure and impaired mental function was …
Lead and aluminum concentrations in water may be dangerous to the health of the population.
PMID: Environ Health Perspect. 1979 Jun ;30:47-51. PMID: 446457 Abstract Title: Experimental study of biological effects of leads and aluminum following oral administration. Abstract: A wide spectrum of the biological effects of lead and aluminum ions is noted during short-term and long-term oral administration to laboratory animals. The general toxic and gonadotoxic effects of these …
This article describes aluminum hydroxide adjuvants as safe, citing a guinea pig study that only looked at anaphylactic reactions.
PMID: Hum Vaccin Immunother. 2015 ;11(2):477-88. PMID: 25692535 Abstract Title: Advances in aluminum hydroxide-based adjuvant research and its mechanism. Abstract: In the past few decades, hundreds of materials have been tried as adjuvant; however, only aluminum-based adjuvants continue to be used widely in the world. Aluminum hydroxide, aluminum phosphate and alum constitute the main forms …
This paper outlines sources of aluminum exposure and the tolerable weekly intake.
PMID: Environ Sci Eur. 2017 ;29(1):19. Epub 2017 Apr 12. PMID: 28458989 Abstract Title: Migration of aluminum from food contact materials to food-a health risk for consumers? Part I of III: exposure to aluminum, release of aluminum, tolerable weekly intake (TWI), toxicological effects of aluminum, study design, and methods. Abstract: BACKGROUND: In spite of the …
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Brain aluminum entry from the blood may involve transferrin-receptor mediated endocytosis and not all aluminum that enters the brain is effluxed as aluminum citrate.
PMID: Neurotoxicology. 2000 Oct ;21(5):813-28. PMID: 11130287 Abstract Title: The toxicology of aluminum in the brain: a review. Abstract: Aluminum is environmentally ubiquitous, providing human exposure. Usual human exposure is primarily dietary. The potential for significant Al absorption from the nasal cavity and direct distribution into the brain should be further investigated. Decreased renal function …
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