PMID: Biomed Pharmacother. 2019 Nov 7 ;121:109602. Epub 2019 Nov 7. PMID: 31707349 Abstract Title: Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2. Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in China, accompanied by an extremely …
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Aluminum’s toxic effects may be due to its ability to displace other essential metals.
PMID: Przegl Lek. 2000 ;57(11):665-8. PMID: 11293216 Abstract Title: [Aluminum–occurrence and toxicity for organisms]. Abstract: Aluminium (Al.) is an ubiquitous element found in every food product. The sources of Al. are especially corn, yellow cheese, salt, herbs, spices, tea and tap water. In household Al.-made ware is a major source of the element. Al. may …
According to Sir Austin Bradford Hill’s causality criteria, chronic aluminum intake causes Alzheimer’s disease.
PMID: J Alzheimers Dis. 2014 ;40(4):765-838. PMID: 24577474 Abstract Title: Chronic aluminum intake causes Alzheimer's disease: applying Sir Austin Bradford Hill's causality criteria. Abstract: Industrialized societies produce many convenience foods with aluminum additives that enhance various food properties and use alum (aluminum sulfate or aluminum potassium sulfate) in water treatment to enable delivery of large …
Chronic exposure to aluminum is associated with increased risk of Alzheimer’s disease.
PMID: Neurosci Lett. 2016 Jan 1 ;610:200-6. Epub 2015 Nov 27. PMID: 26592479 Abstract Title: Chronic exposure to aluminum and risk of Alzheimer's disease: A meta-analysis. Abstract: A meta-analysis was performed to investigate whether chronic exposure to aluminum (Al) is associated with increased risk of Alzheimer's disease (AD). Eight cohort and case-control studies (with a …
This review describes the cellular metabolism of aluminum ions and how they relate to neurodegeneration.
PMID: Environ Health Perspect. 1986 Mar ;65:363-441. PMID: 2940082 Abstract Title: Metabolism and possible health effects of aluminum. Abstract: Literature regarding the biochemistry of aluminum and eight similar ions is reviewed. Close and hitherto unknown similarities were found. A hypothetical model is presented for the metabolism, based on documented direct observations of Al3+ and analogies …
Sensory quality of essential oils and their synergistic effect with diatomaceous earth, for the control of stored grain insects.
PMID: Insects. 2019 Apr 20 ;10(4). Epub 2019 Apr 20. PMID: 31010046 Abstract Title: Sensory Quality of Essential Oils and Their Synergistic Effect with Diatomaceous Earth, for the Control of Stored Grain Insects. Abstract: Essential oils (EOs) have gained increasing interest as a low-toxic, eco-friendly alternative to synthetic repellents and insecticides against insect pests. However, …
Celastrol promotes weight loss in diet-induced obesity.
PMID: J Med Chem. 2018 12 27 ;61(24):11144-11157. Epub 2018 Dec 7. PMID: 30525586 Abstract Title: Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus. Abstract: Celastrol is a natural pentacyclic triterpene used in traditional Chinese medicine with significant weight-lowering effects. Celastrol-administered mice at 100μg/kg …
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Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.
PMID: Int Immunopharmacol. 2019 Jan ;66:215-223. Epub 2018 Nov 22. PMID: 30472522 Abstract Title: Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats. Abstract: Pyroptosis pathway is closely related to inflammation. However, Celastrol effect on pyroptosis pathway after spinal cord injury (SCI) are poorly understood. We studied the anti-inflammatory and …
Celastrol alleviates chronic obstructive pulmonary disease by inhibiting cellular inflammation induced by cigarette smoke.
PMID: Front Pharmacol. 2018 ;9:1276. Epub 2018 Nov 15. PMID: 30498444 Abstract Title: Celastrol Alleviates Chronic Obstructive Pulmonary Disease by Inhibiting Cellular Inflammation Induced by Cigarette Smoke via the Ednrb/Kng1 Signaling Pathway. Abstract: Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic exposure to cigarette smoke (CS). Celastrol is a pentacyclic triterpenoid …
Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells
PMID: Onco Targets Ther. 2018 ;11:8977-8985. Epub 2018 Dec 11. PMID: 30588010 Abstract Title: Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells. Abstract: Background: Celastrol is a major active component of the thunder god vine () used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K-Akt-mTOR signaling, which …
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