PMID: J Ocul Pharmacol Ther. 2019 Mar ;35(2):116-123. Epub 2018 Dec 31. PMID: 30596540 Abstract Title: Celastrol Ameliorates Inflammation in Human Retinal Pigment Epithelial Cells by Suppressing NF-κB Signaling. Abstract: PURPOSE: Celastrol is a triterpenoid quinine methide that exerts important biological effects on a variety of disease models. In this study, we aim to assess …
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The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms.
PMID: Aging Cell. 2019 Jun ;18(3):e12874. Epub 2019 Mar 1. PMID: 30821426 Abstract Title: The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms. Abstract: The prevalence of obesity increases with age in humans and in rodents. Age-related obesity is characterized by leptin resistance and associated with heightened risk of metabolic disorders. However, the …
These findings strongly suggest the potential of celastrol to effectively kill cancer stem-like cells.
PMID: Oxid Med Cell Longev. 2019 ;2019:6793957. Epub 2019 Aug 14. PMID: 31485297 Abstract Title: Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells. Abstract: Cancer resistance to chemotherapy is closely related to tumor heterogeneity, i.e., the existence of distinct subpopulations of cancer cells in a …
Celastrol pretreatment as a therapeutic option against cisplatin-induced nephrotoxicity.
PMID: Toxicol Res (Camb). 2019 Sep 1 ;8(5):723-730. Epub 2019 Jul 31. PMID: 31588349 Abstract Title: Celastrol pretreatment as a therapeutic option against cisplatin-induced nephrotoxicity. Abstract: Celastrol is a natural bioactive compound extracted from the medicinal plantHook F. It exhibits immunosuppressive, anti-inflammatory, and antioxidant activities. Cisplatin is a commonly used chemotherapeutic drug in the treatment …
Celastrol inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells.
PMID: Int J Ophthalmol. 2019 ;12(10):1517-1523. Epub 2019 Oct 18. PMID: 31637185 Abstract Title: Celastrol inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells. Abstract: AIM: To investigate the mechanism of celastrol in inhibiting lens epithelial cells (LECs) fibrosis, which is the pathological basis of cataract.METHODS: Human LEC line SRA01/04 was …
Molecular mechanism of celastrol in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology.
PMID: Life Sci. 2019 Nov 14:117063. Epub 2019 Nov 14. PMID: 31734262 Abstract Title: Molecular mechanism of celastrol in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology. Abstract: BACKGROUND: Network pharmacology uses bioinformatics to broaden our understanding of drug actions and thereby advance drug discovery. Here we apply network …
Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin.
PMID: EBioMedicine. 2019 Nov 14. Epub 2019 Nov 14. PMID: 31735550 Abstract Title: Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin. Abstract: BACKGROUND: Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related death during childhood. Due to their diffuse growth characteristics, chemoresistance and location behind the blood-brain barrier (BBB), …
Celastrol Induces Necroptosis and Ameliorates inflammation via targeting biglycan in human gastric carcinoma.
PMID: Int J Mol Sci. 2019 Nov 14 ;20(22). Epub 2019 Nov 14. PMID: 31739592 Abstract Title: Celastrol Induces Necroptosis and Ameliorates Inflammation via Targeting Biglycan in Human Gastric Carcinoma. Abstract: Celastrol, a triterpene isolated from the root of traditional Chinese medicine, possesses anti-cancer and anti-inflammatory activity to treat rheumatoid disease or as health product. …
Celastrol exerts anti-inflammatory effect in liver fibrosis.
PMID: J Cell Mol Med. 2019 Nov 19. Epub 2019 Nov 19. PMID: 31742890 Abstract Title: Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling. Abstract: Celastrol, a pentacyclic tritepene extracted from Tripterygium Wilfordi plant, showing potent liver protection effects on several liver-related diseases. However, the anti-inflammatory potential of celastrol in liver …
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The combination of gastrodin and rhynchophylline exerts neuroprotective effects by preventing ischaemia-induced inflammasome activation.
PMID: Life Sci. 2019 Oct 11 ;239:116935. Epub 2019 Oct 11. PMID: 31610203 Abstract Title: Gastrodin combined with rhynchophylline inhibits cerebral ischaemia-induced inflammasome activation via upregulating miR-21-5p and miR-331-5p. Abstract: BACKGROUND: The protective effects of gastrodin and rhynchophylline in ischaemic injury have been reported. However, the underlying mechanism and the effect of the combination of …
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